115256-13-8

Basic information

• Product Name: N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine
• Synonyms: N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ethanamine;N-METHYL-N-(2-(4-AMINOPHENOXY)ETHYL)-2-(4-AMINOPHENYL)EHTANAMINE;Benzeneethanamine,4-amino-N-[2-(4-aminophenoxy)et;4-AMINO-N-[2-(4-AMINOPHENOXY)ETHYL]-N-METHYLPHENYLETHYLAMINE;Benzeneethanamine, 4-amino-N-[2-(4-aminophenoxy)ethyl]-N-methyl-;4-(2-((4-AMinophenethyl)(Methyl)aMino)ethoxy)aniline;N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtamine;4-Amino-N-[2-(4-aminophenoxy)ethyl]-N-methylbenzeneethanamine
• CAS NO: 115256-13-8
• Molecular Formula: C₁₇H₂₃N₃O
• Molecular Weight: 285.38
• Product Categories: API intermediates
• Mol File: 115256-13-8.mol

Chemical Properties

• Melting Point: 121 °C
• Boiling Point: 488.334 °C at 760 mmHg
• Flash Point: 249.135 °C
• Appearance: /
• Density: 1.133 g/cm³
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 8.70±0.50(Predicted)
• Stability: Air Sensitive (Turns Brown)
• CAS DataBase Reference: N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine(115256-13-8)
• EPA Substance Registry System: N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine(115256-13-8)

Safety Data

• Hazardous Substances Data: 115256-13-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine is used as a potassium channel blocker for various medical applications. As an analogue of Dofetilide, it plays a crucial role in the treatment of certain cardiovascular conditions by regulating the flow of potassium ions through cell membranes, which can help stabilize the electrical activity of the heart.
Used in Research and Development:
In addition to its pharmaceutical applications, N-Methyl-N-(2-(4-aminophenoxy)ethyl)-2-(4-aminophenyl)ehtanamine is also utilized in research and development settings. Scientists and researchers employ this compound to study the effects of potassium channel blockers on cellular processes and to develop new therapeutic strategies for a range of medical conditions.
Used in Drug Design and Synthesis:
The compound is also used in drug design and synthesis, where it serves as a starting point or a key intermediate for the development of novel potassium channel blockers with improved pharmacological properties. These new compounds may offer better efficacy, reduced side effects, or targeted delivery to specific tissues or organs.

Upstream product

• 85176-37-0 N-methyl-N-[2-(4-nitro-phenyl)-ethyl]-amine 
• 115287-37-1 1-(4-nitrophenoxy)-2-ethane 
• 3383-72-0 1-(2-chloroethoxy)-4-nitrobenzene 

Downstream Products

• 115256-11-6 dofetilide 

Relevant articles and documents

A preparing method of a dofetilide intermediate

A preparing method of a dofetilide intermediate and analogues thereof is disclosed. The method includes steps of dissolving a compound of the formula (I) into a reaction solvent, converting -NO2 of the compound of the formula (I) into -NH2 through hydroge

Dofetilide polymorphs

PCT No. PCT/EP98/06641 Sec. 371 Date Nov. 16, 1999 Sec. 102(e) Date Nov. 16, 1999 PCT Filed Oct. 9, 1998 PCT Pub. No. WO99/21829 PCT Pub. Date May 6, 1999The invention relates to the substantially pure dofetilide polymorphs P162, P162a and P143, and to processes for the preparation of, compositions containing and to the uses of, such polymorphs.

Selective class III antiarrhythmic agents. 1. Bis(arylalkyl)amines

A series of bis(arylalkyl)amines is described and their effects on prolonging effective refractory period in isolated cardiac tissue listed. Most compounds prolonged the cardiac action potential without significantly altering the maximum rate of depolarization and may be defined as selective class III antiarrhythmic agents. It was found that a particularly advantageous structural feature was to have a methanesulfonamido moiety on both of the aryl rings. Thus, compound 16 [1-(4-methanesulfonamidophenoxy)-2-[N-(4-methanesulfonamidophenethyl)- N-methylamine]ethane] was selected for further investigations. The compound is highly potent and selective class III agent which acts by blockade of cardiac potassium channels.

Anti-arrhythmic agents

A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl)amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.