3383-72-0Relevant articles and documents
Ion complexation-controlled columnar mesophase of calix[4]arene-cholesterol derivatives with Schiff-base bridges
Zhang, Xiaoyi,Guo, Hongyu,Yang, Fafu,Yuan, Jin
, p. 905 - 909 (2016)
Two novel calix[4]arene-cholesterol derivatives 7a and 7b with Schiff-base bridges were synthesized in yields of 70-80%. Their structural and conformational characterization had been achieved by NMR, MS, and elemental analysis. Their mesomorphic behaviors were studied by polarizing optical microscopy, differential scanning calorimetry, and X-ray diffraction. They possess mesomorphic properties with the molecular arrangement of the calixarene bowlic column and Schiff-based cholesterol unit as ancillary lateral column. The complexes of 7a and 7b with AgClO4 showed no mesophase. These results suggested that the mesophase of compounds 7a and 7b could be tuned by the ion-complexation behavior.
Dithiocarbamate type compound used as BTK (Bruton Tyrosine Kinase) inhibitor
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Paragraph 0089; 0090; 0091, (2019/04/27)
The invention aims at providing a dithiocarbamate type compound used as a BTK (Bruton Tyrosine Kinase) inhibitor and a pharmaceutical composition thereof, a preparation method and application. The compound provided by the invention has a structure shown as a general formula (I). The formula (I) is shown in the description.
Palladium catalyzed chloroethoxylation of aromatic and heteroaromatic chlorides: An orthogonal functionalization of a chloroethoxy linker
Petho, Bálint,Vangel, Dóra,Csenki, János T.,Zwillinger, Márton,Novák, Zoltán
supporting information, p. 4895 - 4899 (2018/07/15)
A novel disconnection based on cross-coupling chemistry was designed to access pharmaceutically relevant aryl-aminoethyl ethers. The developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with a sodium tetrakis-(2-chloroethoxy) borate salt is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. The transformation enables efficient 2-chloroethoxylation in the absence of an additional external base. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The applicability of this method was demonstrated through the synthesis of various aryl- and heteroaryl-alkyl ethers, including the intermediates of marketed drug molecules.