115666-43-8Relevant articles and documents
Synthesis of Pyranocyclopentaindolines Representing the Western Sections of Janthitrem B, JBIR-137, and Shearinine G
Fresia, Marvin,Lindel, Thomas
supporting information, (2022/02/05)
The synthesis of the ABCD tetracyclic partial structures of the fungal indole diterpenes janthitrem B, JBIR-137, and shearinine G is reported. The route starts from 5-formylated indoline that is coupled to a dihydropyran moiety, followed by Prins cyclization. A diene was obtained that was oxygenated in a divergent manner. The hydroxylated tetracyclic western half of janthitrem B was obtained in eight steps and 10 % overall yield. We also share our experience with alternative approaches passing via alkynylated precursors. This includes the gold-catalyzed cycloisomerization of a 6-ethynyl-5-prenylindoline.
METHODS FOR TREATING HEPATITIS C
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Page/Page column 447, (2010/10/20)
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment
Synthesis of linear tripeptides for right-hand segments of complestatin
Yamada, Yaeko,Akiba, Ai,Arima, Shiho,Okada, Chiharu,Yoshida, Kiminari,Itou, Fumihiro,Kai, Toshitsugu,Satou, Toshiko,Takeda, Kazuyoshi,Harigaya, Yoshihiro
, p. 1277 - 1290 (2007/10/03)
This paper concerns a synthetic study of the right-hand segment of complestatin, an inhibitor of gp120-CD4 receptor. The effective synthesis of four important precursors for the right-hand segment of complestatin is described. Two of them are the precurso
A REGIOSELECTIVE AND COMMON SYNTHETIC METHOD OF DIHALOGENOINDOLES AND ITS APPLICATION FOR THE TOTAL SYNTHESES OF MARINE ALKALOIDS, 4,6-DIBROMO-, 4,6-DIBROMO-2-METHYL-, 3,4,5-TRIBROMOINDOLE
Ohta, Toshiharu,Yamato, Yoshinori,Tahira, Hiroko,Somei, Masanori
, p. 2817 - 2822 (2007/10/02)
A regioselective and common synthetic method for indoles carrying two different kinds of halogens was developed and applied successfully to the total syntheses of marine alkaloids, 4,6-dibromo- and 3,4,5-tribromoindole.The first total synthesis of 4,6-dibromo-2-methylindole is also reported.