22949-08-2Relevant articles and documents
METHODS FOR TREATING HEPATITIS C
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Page/Page column 447, (2010/10/20)
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment
New antiproliferative benzoindolinothiazepines derivatives
Laconde, Guillaume,Depreux, Patrick,Berthelot, Pascal,Pommery, Nicole,Henichart, Jean-Pierre
, p. 167 - 172 (2007/10/03)
New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.
5H-[1,2,5]selenadiazolo[3,4-f]indole as a masked form of 5,6-diaminoindole
Okwakol, Jealux,Grivas, Spiros
, p. 1939 - 1946 (2007/10/03)
6-Nitroindoline (9) was converted into 1-acetyl-5,6-aminoindoline (12) which was then transformed via selenadiazoles (13-15) to the title selenadiazoloindole (4) by two alternative 3-step synthetic sequences in 38-42% overall yield from 12. The unstable 5,6-diaminoindole (16) was then obtained by reductive deselenation of 4. Fully assigned 1H, 13C and 77Se NMR spectral data for the title indole (4) and 77Se NMR spectral data for the intermediate selenadiazoles (13-15) are presented.
Synthesis of linear tripeptides for right-hand segments of complestatin
Yamada, Yaeko,Akiba, Ai,Arima, Shiho,Okada, Chiharu,Yoshida, Kiminari,Itou, Fumihiro,Kai, Toshitsugu,Satou, Toshiko,Takeda, Kazuyoshi,Harigaya, Yoshihiro
, p. 1277 - 1290 (2007/10/03)
This paper concerns a synthetic study of the right-hand segment of complestatin, an inhibitor of gp120-CD4 receptor. The effective synthesis of four important precursors for the right-hand segment of complestatin is described. Two of them are the precurso
Photo-induced rearrangement of 1-ethoxy-2-phenylindole
Yamada, Koji,Somei, Masanori
, p. 2481 - 2484 (2007/10/03)
Photoirradiation of 1-ethoxy-2-phenylindole in methanol afforded 3- and 6-ethoxy-2-phenylindoles. The structural determination of the latter is carried out by direct comparison of its spectral data with those of the authentic 4-, 5-, 6-, and 7-ethoxy-2-phenylindoles, whose syntheses are also included.