22949-08-2

Basic information

• Product Name: 1-Acetyl-2,3-dihydro-6-nitro-1H-indole
• Synonyms: 1-Acetyl-2,3-dihydro-6-nitro-1H-indole;1-Acetyl-6-Nitroindole;1-(6-Nitroindolin-1-yl)ethanone;Ethanone, 1-(2,3-dihydro-6-nitro-1H-indol-1-yl)-;1-(6-nitro-1-indolinyl)ethanone;1H-Indole, 1-acetyl-2,3-dihydro-6-nitro-;Indoline, 1-acetyl-6-nitro-;1-(6-Nitroindolin-1-yl)
• CAS NO: 22949-08-2
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.2
• Mol File: 22949-08-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 450.9 °C at 760 mmHg
• Flash Point: 226.5 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 2.54E-08mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Acetyl-2,3-dihydro-6-nitro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-2,3-dihydro-6-nitro-1H-indole(22949-08-2)
• EPA Substance Registry System: 1-Acetyl-2,3-dihydro-6-nitro-1H-indole(22949-08-2)

Safety Data

• Hazardous Substances Data: 22949-08-2(Hazardous Substances Data)

Usage

General Description

1-Acetyl-2,3-dihydro-6-nitro-1H-indole is a chemical compound with the molecular formula C11H11N3O3. It is a yellow powder that has the potential to be used in pharmaceutical and chemical research. 1-Acetyl-2,3-dihydro-6-nitro-1H-indole has been studied for its potential as an anticancer agent due to its ability to inhibit the growth of cancer cells. It has also shown potential as an anti-inflammatory and analgesic compound. Additionally, it has been investigated for its antibacterial and antifungal properties. As a nitro-substituted indole derivative, 1-Acetyl-2,3-dihydro-6-nitro-1H-indole has the potential for further research and development for various applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H10N2O3/c1-7(13)11-5-4-8-2-3-9(12(14)15)6-10(8)11/h2-3,6H,4-5H2,1H3

Upstream product

• 496-15-1 1-indoline 
• 19727-83-4 6-nitroindoline 
• 108-24-7 acetic anhydride 

Downstream Products

• 220657-60-3 1-acetyl-6-ethoxy-2,3-dihydroindole 
• 4770-34-7 1-acetyl-6-hydroxy-2,3-dihydroindole 
• 849355-52-8 methyl N-(1-acetylindolin-6-yl)-N-methyl-2-sulfamoyl benzoate 
• 849355-53-9 N-(1-acetylindolin-6-yl)-N-methyl-2-sulfamoyl benzoic acid 
• 849355-51-7 methyl N-(1-acetylindolin-6-yl)-2-sulfamoyl benzoate 
• 115666-43-8 1-acetyl-2,3-dihydro-6-iodoindole 
• 115666-46-1 6-iodo-2,3-dihydro-1H-indole 
• 115666-47-2 6-iodo-1 H-indole 
• 872876-95-4 (R,R)-3-{6-[3-(N-tert-butoxycarbonyl-2-methoxycarbonylmethylamino)-5-iodo-6-methoxyphenyl]indol-3-yl}-2-carbobenzyloxyaminopropionic acid tert-butyl ester 
• 872876-83-0 (R,R)-(6'-iodo-N-carbobenzyloxytryptophyl)-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester 
• 872877-18-4 (R)-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-N-carbobenzyloxy-6'-iodotryptophan tert-butyl ester 
• 872877-20-8 (R)-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-N-carbobenzyloxytryptophan 
• 872876-93-2 (R)-N-carbobenzyloxy-6'-iodotryptophan tert-butyl ester 
• 872877-29-7 (S)-N-carbobenzyloxy-6'-iodotryptophan 

Relevant articles and documents

METHODS FOR TREATING HEPATITIS C

In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment

5H-[1,2,5]selenadiazolo[3,4-f]indole as a masked form of 5,6-diaminoindole

6-Nitroindoline (9) was converted into 1-acetyl-5,6-aminoindoline (12) which was then transformed via selenadiazoles (13-15) to the title selenadiazoloindole (4) by two alternative 3-step synthetic sequences in 38-42% overall yield from 12. The unstable 5,6-diaminoindole (16) was then obtained by reductive deselenation of 4. Fully assigned 1H, 13C and 77Se NMR spectral data for the title indole (4) and 77Se NMR spectral data for the intermediate selenadiazoles (13-15) are presented.

Photo-induced rearrangement of 1-ethoxy-2-phenylindole

Photoirradiation of 1-ethoxy-2-phenylindole in methanol afforded 3- and 6-ethoxy-2-phenylindoles. The structural determination of the latter is carried out by direct comparison of its spectral data with those of the authentic 4-, 5-, 6-, and 7-ethoxy-2-phenylindoles, whose syntheses are also included.