115886-00-5Relevant articles and documents
(4-HYDROXYPYRROLIDIN-2-YL)-HYDROXAMATE COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0737, (2019/05/15)
The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.
Excitatory Amino Acids. Improved Synthesis of Ibotenic Acid and X-Ray Analysis of an Unexpected Reaction Product, (RS)-N--3-oxobutyramide
Madsen, Ulf,Brehm, Lotte,Krogsgaard-Larsen, Povl
, p. 359 - 364 (2007/10/02)
A new synthesis of the excitotoxic natural product ibotenic acid (1) is described.Benzylation of 3-hydroxy-5-methylisoxazole (5) yielded 3-benzyloxy-5-methylisoxazole (7) and the isomeric isoxazol-3(2H)-one (6).While metallation of compound (7) by lithium