1159-15-5

Basic information

• Product Name: TOS-ARG-OH
• Synonyms: TOS-ARGININE;TOS-ARG-OH;TOSYL-L-ARGININE;P-TOSYL-L-ARG;P-TOSYL-L-ARGININE;P-TOLUENESULFONYL-L-ARGININE;N-TOSYL-L-ARGININE;N-P-TOSYL-L-ARGININE
• CAS NO: 1159-15-5
• Molecular Formula: C₁₃H₂₀N₄O₄S
• Molecular Weight: 328.39
• Product Categories: Amino Acids;Arginine [Arg, R];Amino Acids and Derivatives
• Mol File: 1159-15-5.mol

Chemical Properties

• Boiling Point: 591.3 °C at 760 mmHg
• Flash Point: 311.4 °C
• Appearance: /Solid
• Density: 1.42 g/cm³
• Vapor Pressure: 7.95E-15mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: TOS-ARG-OH(CAS DataBase Reference)
• NIST Chemistry Reference: TOS-ARG-OH(1159-15-5)
• EPA Substance Registry System: TOS-ARG-OH(1159-15-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 1159-15-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
TOS-ARG-OH is used as a research compound for exploring its potential applications in drug development. The combination of tosyl, arginine, and hydroxide may offer unique properties that can be harnessed in the creation of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, TOS-ARG-OH serves as a modified amino acid derivative, potentially used as an intermediate or a building block in the synthesis of complex organic molecules, taking advantage of the tosyl group's role as a protecting group.
Used in Metabolic Pathway Studies:
Given arginine's involvement in various metabolic pathways, TOS-ARG-OH may be utilized in biological research to study the effects of modified amino acids on these pathways, potentially leading to insights into metabolic diseases or the development of metabolic regulators.
Used in Chemical Modification of Biomolecules:
The presence of the hydroxide group in TOS-ARG-OH allows it to be used in the chemical modification of biomolecules, such as proteins or nucleic acids, where it can act as a base to facilitate certain chemical reactions or to neutralize acidic groups.

InChI:InChI=1/C13H20N4O4S/c1-9-4-6-10(7-5-9)22(20,21)17-11(12(18)19)3-2-8-16-13(14)15/h4-7,11,17H,2-3,8H2,1H3,(H,18,19)(H4,14,15,16)

Upstream product

• 74-79-3 L-arginine 
• 98-59-9 p-toluenesulfonyl chloride 
• 19595-40-5 N²-(toluene-4-sulfonyl)-L-ornithine 
• 2440-60-0 2-methyl-isourea 
• 1784-03-8 Nα-tosyl-L-arginine methyl ester hydrochloride 
• 3304-51-6 N-carboxybenzyl-L-ornithine 
• 110414-90-9 N⁵-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-ornithine 
• 102081-75-4 N-(toluene-4-sulfonyl)-L-glutamic acid-1-benzyl ester-5-nitrile 
• 42533-20-0 N-(toluene-4-sulfonyl)-L-glutamic acid-5-nitrile 
• 1031-48-7 N²-(toluene-4-sulfonyl)-L-ornithine methyl ester; hydrochloride 
• 124288-95-5 4-methyl-N-(2-oxopiperidin-3-yl)benzenesulfonamide 
• 4723-71-1 N²-(toluene-4-sulfonyl)-DL-ornithine 
• 122701-40-0 N⁵-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-DL-ornithine 

Downstream Products

• 14279-64-2 N^α-(toluene-4-sulfonyl)-L-arginine amide; hydrochloride 
• 19595-40-5 N²-(toluene-4-sulfonyl)-L-ornithine 
• 74-79-3 L-arginine 
• 1784-03-8 Nα-tosyl-L-arginine methyl ester hydrochloride 

Relevant articles and documents

USE OF OPEN-CHAIN CARBOXYLIC ACIDS, CARBONIC ESTERS, CARBOXAMIDES AND CARBONITRILES OF ARYL, HETEROARYL AND BENZYLSULFONAMIDE OR THE SALTS THEREOF FOR IMPROVING THE STRESS TOLERANCE IN PLANTS

The invention relates to the use of open-chain aryl-, heteroaryl- and benzylsulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I) in which the respective substituents have the meanings given

Purification and characterization of trypsin from the spleen of tongol tuna (Thunnus tonggol)

Trypsin from tongol tuna (Thunnus tonggol) spleen was purified to 402-fold by ammonium sulfate precipitation, followed by a series of chromatographic separations. The molecular mass of trypsin was estimated to be 24 kDa by size-exclusion chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Trypsin appearing as a single band on native PAGE showed the maximal activity at pH 8.5 and 65°C. It was stable in a wide pH range of 6-11 but unstable at the temperatures greater than 50°C. The enzyme required calcium ion for thermal stability. The activity was strongly inhibited by 1.0 g/L soybean trypsin inhibitor and 5 mM TLCK and partially inhibited by 2 mM ethylenediaminetetraacetic acid. Activity was lowered with an increasing NaCl concentration (0-30%). The enzyme had a Km for N α-p-tosyl-L-arginine methyl ester hydrochloride of 0.25 mM and a Kcat of 200 s-1. The N-terminal amino acid sequence of trypsin was determined as IVGGYECQAHSQPHQVSLNA and was very homologous to other trypsins.