116337-58-7Relevant articles and documents
Heterocyclic Oxime Compounds, A Process For Their Preparation And Pharmaceutical Compositions Containing Them.
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Page/Page column 7, (2008/12/05)
Compounds of formula (I): wherein: X represents an oxygen atom or a sulphur atom,R1, R2, R3 and R4 are as defined in the description,A represents an alkylene chain as defined in the description, andB represents
Aromatase inhibitor compounds and uses thereof
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Page/Page column 4, (2010/11/26)
The invention concerns the use of a compound of formula (I) inhibitor of aromatase for the preparation of a pharmaceutical formulation intended for treatment of cancer or psoriasis. It equally relates to compounds of formula (I), notably for their use as active ingredients of a medication.
Acyl-7 dihydro-2,3 benzoxazin-1,4 ones-3 et proprietes normolipemiantes
Moussavi, Ziaeddine,Lesieur, Daniel,Lespagnol, Charles,Sauzieres, Jacques,Olivier, Philippe
, p. 55 - 60 (2007/10/02)
7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones and normolipemic properties.Fibrates are still among the most widely used drugs for the treatment of dyslipoproteinemia. 7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones (Fig.1B) can be considered as conformationally restrained analogues of fibrates, such as fenofibrate.These compounds have been prepared and studied for their normolipemic activity particularly on plasma cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol levels.Hepatotoxicity and mutagenicity have also been evaluated.Some of them show an interesting activity, quite comparable to fenofibrate, and are devoid of hepatotoxicity. hyperlipidemia / hypocholesterolemic drugs / fibrates / 7-acyl-1,4-benzoxazin-3-ones