116862-22-7

Basic information

• Product Name: 6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 6-chloro-7-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one;6-chloro-7-nitro-4H-1,4-benzoxazin-3-one
• CAS NO: 116862-22-7
• Molecular Formula: C₈H₅ClN₂O₄
• Molecular Weight: 228.59
• Mol File: 116862-22-7.mol

Chemical Properties

• Melting Point: >250 °C(Solv: acetone (67-64-1))
• Boiling Point: 448.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.591±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.35±0.20(Predicted)
• CAS DataBase Reference: 6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE(116862-22-7)
• EPA Substance Registry System: 6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE(116862-22-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 116862-22-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE is used as a key intermediate in the synthesis of various organic compounds due to its reactive functional groups and structural features. Its presence in organic reactions can lead to the formation of a wide range of products, making it valuable in the development of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE is utilized as a potential drug candidate or a precursor in the synthesis of pharmaceutically active compounds. Its unique structure may contribute to the development of new drugs with novel mechanisms of action or improved therapeutic profiles.
Used as a Building Block in Synthesis:
6-CHLORO-7-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE is employed as a building block for the synthesis of more complex organic molecules. Its incorporation into larger molecular frameworks can lead to the creation of new compounds with diverse applications in various fields, including materials science, agrochemicals, and specialty chemicals.

Upstream product

• 7652-29-1 6-chloro-2H-1,4-benzoxazin-3(4H)-one 
• 6358-07-2 2-amino-4-chloro-5-nitrophenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 116862-25-0 6-(3-Methoxy-phenylsulfanyl)-7-nitro-4H-benzo[1,4]oxazin-3-one 
• 123282-26-8 4-Benzyl-4,8-dihydro-1-oxa-5-thia-4,8-diaza-anthracene-3,7-dione 
• 123282-28-0 4-(4-Methyl-benzyl)-4,8-dihydro-1-oxa-5-thia-4,8-diaza-anthracene-3,7-dione 
• 123282-27-9 4-Benzyl-6-methyl-4,8-dihydro-1-oxa-5-thia-4,8-diaza-anthracene-3,7-dione 
• 123282-33-7 4-Benzyl-4,7,8,10-tetrahydro-1-oxa-6-thia-4,10-diaza-cyclohepta[b]naphthalene-3,9-dione 
• 123282-29-1 6-Methyl-4-(4-methyl-benzyl)-4,8-dihydro-1-oxa-5-thia-4,8-diaza-anthracene-3,7-dione 
• 123282-19-9 3-(7-Amino-4-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid 
• 123282-11-1 2-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid 
• 123282-15-5 3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid 
• 40401-45-4 7-amino-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 116862-42-1 7-Amino-6-(4-phenyl-piperazin-1-yl)-4H-benzo[1,4]oxazin-3-one 
• 116862-26-1 7-Amino-6-phenylsulfanyl-4H-benzo[1,4]oxazin-3-one 
• 116862-55-6 6-(4-Benzyl-piperazin-1-yl)-7-isothiocyanato-4H-benzo[1,4]oxazin-3-one 
• 116862-31-8 6-(3-Methoxy-benzenesulfonyl)-7-nitro-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, wherein R1 and Cy are as disclosed herein. These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.

FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS

A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused mor

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

The bromination and nitration of some (2H)-1,4-benzoxazin-3(4H)-ones

Bromination of (2H)-1,4-benzoxazin-3-(4H)-one with bromine in glacial acetic acid gave firstly the 6-bromo and then the 6,7-dibromo compound whilst bromine in chloroform gave mainly the 7-bromo derivative. Bromination of the 6-chloro- and 6-methyl-(2H)-1,4-benzoxazin-3(4H)-ones and (2H)=1,4-benzothiazin-3(4H)-one gave the 7-bromo compounds. Nitration of (2H)-1,4-benzoxazin-3(4H)-one with a sulfuric acid : nitric acid mixture gave the 6-nitro and then 6,8-dinitro compound whilst nitrosation: nitration with sodium nitrite : fuming nitric acid gave mainly the 7-nitro compound. 6-Chloro-(2H)-1,4-benzoxazin-3(4H)-one gave 7-nitro compound.

Synthesis and Anthelmintic Activity of Some New 6-(Arylthio-/arylsulfonyl/substitutedamino)-7-isothiocyanato-2H-1,4-benzoxazin-3(4H)-ones

A series of 6-arylthio, -arylsulfonyl-, and -substitutedamino-7-isothiocyanato-2H-1,4-benzoxazin-3(4H)-ones (26-37) has been prepared and evaluated for anthelmintic activity.