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Cas Database

117332-89-5

117332-89-5

Identification

  • Product Name:Acetyl Fentanyl HCl

  • CAS Number: 117332-89-5

  • EINECS:

  • Molecular Weight:0

  • Molecular Formula: C21H26N2O*ClH

  • HS Code:

  • Mol File:117332-89-5.mol

Synonyms:Acetyl Fentanyl HCl

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Relevant articles and documentsAll total 1 Articles be found

An efficient, optimized synthesis of fentanyl and related analogs

Valdez, Carlos A.,Leif, Roald N.,Mayer, Brian P.

, (2015/02/19)

The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.

Process route upstream and downstream products

Process route

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide
3258-84-2

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 2h;
96%
4-piperidone hydrochloride
41979-39-9

4-piperidone hydrochloride

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: caesium carbonate / acetonitrile / 5 h / 80 °C
2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling with ice
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
4: hydrogenchloride / diethyl ether; water / 2 h / 20 °C
With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; water; acetonitrile;
1-(2-phenylethyl)-4-piperidinone
39742-60-4

1-(2-phenylethyl)-4-piperidinone

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling with ice
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
3: hydrogenchloride / diethyl ether; water / 2 h / 20 °C
With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; water;
1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: caesium carbonate / acetonitrile / 5 h / 80 °C
2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling with ice
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
4: hydrogenchloride / diethyl ether; water / 2 h / 20 °C
With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; water; acetonitrile;
(1-Phenethyl-piperidin-4-yl)-phenyl-amine
21409-26-7

(1-Phenethyl-piperidin-4-yl)-phenyl-amine

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
2: hydrogenchloride / diethyl ether; water / 2 h / 20 °C
With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; water;
N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride
117332-89-5

N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride

N-phenyl-N-(piperidin-4-yl)acetamide hydrochloride
22352-82-5

N-phenyl-N-(piperidin-4-yl)acetamide hydrochloride

Conditions
Conditions Yield
With NADPH; cytochrome P450; In aq. phosphate buffer; ethanol; acetonitrile; at 20 ℃; pH=7.4; Enzymatic reaction;

Global suppliers and manufacturers

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
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