3258-84-2

Usage

Uses

Used in Clinical Toxicology:
N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE is used as a starting material for calibrators and controls in fentanyl testing methods to ensure accurate and reliable results in clinical toxicology applications.
Used in Urine Drug Testing:
N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE is utilized as a reference material in the development and validation of urine drug testing methods, helping to identify and quantify the presence of fentanyl and its analogs in urine samples.
Used in Prescription Monitoring:
N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE serves as a reference substance in prescription monitoring programs, assisting in the detection and prevention of prescription drug abuse and diversion.
Used in Forensic Analysis:
This fentanyl analog is employed as a starting material in the development of forensic analysis methods, aiding in the identification and quantification of fentanyl and its analogs in various samples, such as blood, tissue, and other biological matrices.
As a Controlled Substance:
N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-ACETAMIDE is classified as a controlled substance due to its high potency and potential for abuse. It is regulated and monitored to prevent illegal distribution and misuse.

InChI:InChI=1/C21H26N2O/c1-18(24)23(20-10-6-3-7-11-20)21-13-16-22(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,21H,12-17H2,1H3

Upstream product

• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 21409-26-7 (1-Phenethyl-piperidin-4-yl)-phenyl-amine 
• 75-36-5 acetyl chloride 
• 57958-48-2 N-(1-phenethylpiperidin-4-ylidene)aniline 
• 62-53-3 aniline 
• 103-63-9 1-phenyl-2-bromoethane 
• 41979-39-9 4-piperidone hydrochloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 117332-89-5 N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylacetamide Hydrochloride 

Relevant academic research and scientific papers

Evaluation of agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor using a cell-based assay system

The agonistic activity of fluorinated and nonfluorinated fentanyl analogs on μ-opioid receptor was investigated using a cell-based assay system. Based on the activity, fentanyl analogs were ranked as follows: fentanyl>isobutyrylfentanyl≈butyrylfentanyl≈methoxyacetylfentanyl>acetylfentanyl. However, among the fentanyl analogs fluorinated on the Nphenyl ring, 2-fluoro analogs and 3-fluoro analogs showed the strongest and weakest activities, respectively. These results suggest that the 2-fluorinated isomers of fentanyl analogs are more likely to cause poisoning.

An efficient, optimized synthesis of fentanyl and related analogs

The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.

Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs

Natural abundance carbon-13 chemical shifts are reported for the hydrochloride salts of fentanyl and fifteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, comparisons with model compounds, and thiophene carbon-proton coupling constants. In addition to its forensic value, the data suggest that the solution conformations of the analogs are similar to that of fentanyl hydrochloride.