118527-35-8

Basic information

• Product Name: 1-(2,2-Dichloro-1-fluoro-vinyl)-2,4-bis-trifluoromethyl-benzene
• Synonyms: 1-(2,2-Dichloro-1-fluoro-vinyl)-2,4-bis-trifluoromethyl-benzene
• CAS NO: 118527-35-8
• Molecular Weight: 327.029
• Mol File: 118527-35-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2,2-Dichloro-1-fluoro-vinyl)-2,4-bis-trifluoromethyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-Dichloro-1-fluoro-vinyl)-2,4-bis-trifluoromethyl-benzene(118527-35-8)
• EPA Substance Registry System: 1-(2,2-Dichloro-1-fluoro-vinyl)-2,4-bis-trifluoromethyl-benzene(118527-35-8)

Safety Data

• Hazardous Substances Data: 118527-35-8(Hazardous Substances Data)

Upstream product

• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 327-75-3 1-bromo-2,4-di(trifluoromethyl)benzene 
• 402-31-3 1,3-bis(trifluoromethyl)benzene 

Relevant articles and documents

Preparation of Fluorine-Containing Phenylacetylenes by the Method of Introduction of the Ethynyl Group Using 1,1-Dichloro-2,2-difluroethene

Phenylacetylenes (ArCCH) having fluoro- or trifluoromethyl substituents (o-, m-, p-F; o-, m-, p-CF3; 2,4-, 2,5-, 2,6-, 3,5-(CF3)2) have been prepared from bromobenzenes (ArBr) and benzenes (ArH) using 1,1,-dichloro-2,2-difluoroethene (1) by a two-step route: ArLi or ArMgBr->ArCF=CCl2->ArCCLi.Upon careful treatment at -70 deg C with 1, o-fluorophenyllithium gave o-FC6H4CF=CCl2 in good yield, together with benzyne-derived products, such as o-(o-FC6H4)C6H4CF=CCl2.Lithiation of m-bis(trifluoromethyl)benzene at 0 deg C for 9 h (24 h) followed by treatment with bromine gave 1-bromo-2,4-, 2,6-, and 3,5-bis(trifluoromethyl)benzene in 35 (38), 31 (36), and 8percent (6percent) yield, respectively.