327-75-3

Usage

Chemical Properties

clear colorless to slightly brown liquid

Uses

2,4-Bis(trifluoromethyl)bromobenzene may be used in chemical synthesis.

InChI:InChI=1/C8H3ClF6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13,14)15/h1-3H

Upstream product

• 109-65-9 1-bromo-butane 
• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 577-05-9 1-methoxy-2,4-bis-trifluoromethyl-benzene 

Downstream Products

• 577-05-9 1-methoxy-2,4-bis-trifluoromethyl-benzene 
• 306936-81-2 (2,4-bis-trifluoromethyl-phenyl)-oxo-acetic acid ethyl ester 
• 467435-10-5 (2,4-bis-trifluoromethyl-phenyl)-oxo-acetic acid 
• 870194-68-6 [2-(2,4-bis-trifluoromethyl-phenoxy)-ethyl]-carbamic acid tert-butyl ester 
• 153254-09-2 2,4-bis(trifluoromethyl)phenylboronic acid 
• 1186482-21-2 3-(2,4-bis(trifluoromethyl)phenyl)prop-2-yn-1-ol 
• 278187-48-7 1,2,3,4,5,6,7,8-octafluoro-9-hydroxy-9-[2,4-bis(trifluoromethyl) phenyl]fluorene 
• 1226571-79-4 1-((4-methoxyphenyl)ethynyl)-2,4-bis(trifluoromethyl)benzene 
• 1226571-77-2 2,4-bis(trifluoromethyl)-1-((4-(trifluoromethyl)phenyl)ethynyl)benzene 
• 88444-80-8 C₁₃H₁₂F₆Si 
• 1213229-02-7 C₃₄H₂₆F₁₂O₄ 
• 1213228-77-3 (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-diol 
• 1213228-78-4 (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate 

Relevant academic research and scientific papers

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

New strategies in the synthesis of regioselectively trifluoromethyl- and trifluoromethoxy-substituted arenes as building blocks for biologically active molecules

Regioisomerically pure trifluoromethyl- and trifluoromethoxy-substituted aromatic and heteroaromatic aldehydes and carboxylic acids are valuable building blocks for the synthesis of biologically active molecules. They have been prepared by employing moder

Preparation of Fluorine-Containing Phenylacetylenes by the Method of Introduction of the Ethynyl Group Using 1,1-Dichloro-2,2-difluroethene

Phenylacetylenes (ArCCH) having fluoro- or trifluoromethyl substituents (o-, m-, p-F; o-, m-, p-CF3; 2,4-, 2,5-, 2,6-, 3,5-(CF3)2) have been prepared from bromobenzenes (ArBr) and benzenes (ArH) using 1,1,-dichloro-2,2-difluoroethene (1) by a two-step route: ArLi or ArMgBr->ArCF=CCl2->ArCCLi.Upon careful treatment at -70 deg C with 1, o-fluorophenyllithium gave o-FC6H4CF=CCl2 in good yield, together with benzyne-derived products, such as o-(o-FC6H4)C6H4CF=CCl2.Lithiation of m-bis(trifluoromethyl)benzene at 0 deg C for 9 h (24 h) followed by treatment with bromine gave 1-bromo-2,4-, 2,6-, and 3,5-bis(trifluoromethyl)benzene in 35 (38), 31 (36), and 8percent (6percent) yield, respectively.