118617-57-5Relevant articles and documents
Asmic: An Exceptional Building Block for Isocyanide Alkylations
Alwedi, Embarek,Lujan-Montelongo, J. Armando,Pitta, Bhaskar R.,Chao, Allen,Cortés-Mejía, Rodrigo,Del Campo, Jorge M.,Fleming, Fraser F.
, p. 5910 - 5913 (2018)
Asmic addresses the long-standing challenge of alkylating isocyanides, providing access to isocyanides with diverse substitution patterns. The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.
COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF ISONITRILES
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Paragraph 0050, (2015/09/23)
This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.
SYNTHESIS OF CHIRAL SULFONYLMETHYL ISOCYANIDES, AND COMPARISON OF THEIR PROPENSITIES IN ASYMMETRIC INDUCTION REACTIONS WITH ACETOPHENONES
Hundscheid, Frans J. A.,Tandon, Vishnu K.,Rouwette, Pieter H. F. M.,Leusen, Albert M. van
, p. 5073 - 5088 (2007/10/02)
Seven chiral analogues of tosylmethyl isocyanide (TosMIC) were synthesized in order to investigate and compare their ability to achieve asymmetric induction in base mediated reactions with acetophenone and trifluoracetophenone.Acid hydrolysis of the intermediate 2-oxazolines (10 and 11) gave optically active α-hydroxy aldehydes (12 and 13).