Welcome to LookChem.com Sign In|Join Free

CAS

  • or

119532-26-2

Post Buying Request

119532-26-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

119532-26-2 Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 119532-26-2 differently. You can refer to the following data:
1. This product is intended for forensic and research purposes and it is an aripiprazole intermediate.
2. Aripiprazole (A771000) intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 119532-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,3 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 119532-26:
(8*1)+(7*1)+(6*9)+(5*5)+(4*3)+(3*2)+(2*2)+(1*6)=122
122 % 10 = 2
So 119532-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12Cl2N2.2ClH/c11-8-2-1-3-9(10(8)12)14-6-4-13-5-7-14;;/h1-3,13H,4-7H2;2*1H

119532-26-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L18697)  1-(2,3-Dichlorophenyl)piperazine monohydrochloride, 98+%   

  • 119532-26-2

  • 5g

  • 209.0CNY

  • Detail
  • Alfa Aesar

  • (L18697)  1-(2,3-Dichlorophenyl)piperazine monohydrochloride, 98+%   

  • 119532-26-2

  • 25g

  • 743.0CNY

  • Detail
  • Alfa Aesar

  • (L18697)  1-(2,3-Dichlorophenyl)piperazine monohydrochloride, 98+%   

  • 119532-26-2

  • 100g

  • 2418.0CNY

  • Detail
  • USP

  • (1042656)  AripiprazoleRelatedCompoundC  United States Pharmacopeia (USP) Reference Standard

  • 119532-26-2

  • 1042656-25MG

  • 14,500.98CNY

  • Detail
  • Aldrich

  • (679135)  1-(2,3-Dichlorophenyl)piperazinehydrochloride  97%

  • 119532-26-2

  • 679135-5G

  • 712.53CNY

  • Detail

119532-26-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,3-Dichlorophenyl)piperazine hydrochloride

1.2 Other means of identification

Product number -
Other names RARECHEM AH CK 0082

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119532-26-2 SDS

119532-26-2Relevant articles and documents

Synthesis method of cariprazine key intermediate 1-(2,3-dichlorophenyl)piperazine hydrochloride

-

Paragraph 0042-0044; 0051-0056, (2021/11/26)

The invention discloses a synthesis method of a cariprazine key intermediate 1-(2,3-dichlorophenyl)piperazine hydrochloride, and belongs to the field of medicine synthesis. The method comprises the following steps: (1) taking a compound 1 and a compound a as raw materials, and conducting reacting to obtain a compound 2; (2) carrying out nitro reduction reaction by taking the compound 2 and a reducing agent as raw materials to obtain a compound 3; and (3) taking the compound 3 as a raw material, and carrying out diazotization reaction and deprotection reaction to obtain the 1-(2,3-dichlorophenyl)piperazine hydrochloride. The raw materials used in the synthesis method are low in toxicity, low in cost and easy to obtain, no noble metal catalyst or phosphorus ligand is used, the equipment requirement is simple, the product yield is high, the purity is high, and the synthesis method is suitable for large-scale industrial production and has a good application prospect.

Compound with dopamine D3 receptor adjusting activity, and applications thereof

-

Paragraph 0191-0194, (2019/03/22)

The invention relates to a compound with dopamine D3 receptor adjusting activity, and applications thereof, and more specifically discloses dopamine receptor D3R as a novel target of post-traumatic stress disorder (PTSD) in prevention, treatment/or auxiliary treatment of PTSD, and screening of anti-PTSD medicines, and relates to applications of a compound with dopamine receptor D3R adjusting activity in preparation of medicines used for preventing, treatment and/or auxiliary treatment of PTSD.

Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D3 receptor agonists

Cao, Yongkai,Sun, Ningning,Zhang, Jiumei,Liu, Zhiguo,Tang, Yi-zhe,Wu, Zhengzhi,Kim, Kyeong-Man,Cheon, Seung Hoon

supporting information, p. 1457 - 1465 (2018/10/02)

The dopamine D3 receptor (D3R) is a proven therapeutic target for the treatment of neurological and neuropsychiatric disorders. In particular, D3R-selective ligands that can eliminate side effects associated with dopamine D2 receptor (D2R) therapeutics have been validated. However, the high homology in signaling pathways and the sequence similarity between D2R and D3R have rendered the development of D3R-selective ligands challenging. Herein, we designed and synthesized a series of piperazine-phthalimide bitopic ligands based on a fragment-based and molecular docking inspired design. Compound 9i was identified as the most selective D3R ligand among these bitopic ligands. Its selectivity was improved compared to reference compounds 1 and 2 by 9- and 2-fold, respectively, and it was 21-fold more potent than compound 2. Molecular docking demonstrated that the orientation of Leu2.64 and Phe7.39 and the packing at the junction of helices may affect the specificity for D3R over D2R. Functional evaluation revealed that D3R-selective ligand 9i displayed a subpicomolar agonist activity at D3R with a 199-fold increase in potency compared to quinpirole. These results may be useful for the fragment-based design of bitopic compounds as selective D3R ligands.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 119532-26-2