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1205548-00-0

4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide, also known as 4'-Dimethylamino 7,8-Dihydroxyflavone, is a synthetic derivative of 7,8-Dihydroxyflavone. It is an orange-brown solid that has been found to promote neurogenesis and exhibit potent antidepressant effects. The 7,8-dihydroxy groups in its structure are crucial for its agonistic activity, and it has been shown to have higher TrkB agonistic activity than 7,8-Dihydroxyflavone (D452830).

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  • 1205548-00-0 Structure

  • Basic information

    1. Product Name: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide
    2. Synonyms: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide;4'-DiMethylaMino 7,8-Dihydroxyflavone
    3. CAS NO:1205548-00-0
    4. Molecular Formula: BrH*C17H15NO4
    5. Molecular Weight: 297.3053
    6. EINECS: N/A
    7. Product Categories: Agonist;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Agonist, Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 1205548-00-0.mol

  • Chemical Properties

    1. Melting Point: 267.8-270.4 °C(Solv: dichloromethane (75-09-2); methanol (67-56-1))
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: DMSO (Slightly)
    9. CAS DataBase Reference: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide(1205548-00-0)
    11. EPA Substance Registry System: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide(1205548-00-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1205548-00-0(Hazardous Substances Data)

1205548-00-0 Usage

Uses

Used in Pharmaceutical Industry:
4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is used as a pharmaceutical agent for its antidepressant properties. It promotes neurogenesis and has a potent effect on alleviating depressive symptoms. The agonistic activity of this compound makes it a promising candidate for the development of new antidepressant medications.
Used in Research Applications:
In the field of neuroscience and pharmacology, 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is used as a research tool to study the mechanisms underlying neurogenesis and the effects of TrkB agonists on neuronal development and function. Its higher TrkB agonistic activity compared to 7,8-Dihydroxyflavone makes it valuable for investigating the potential therapeutic applications of TrkB agonists in various neurological disorders.
Used in Drug Development:
4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide is utilized in the development of new drugs targeting neurological and psychiatric conditions. Its potent antidepressant effect and promotion of neurogenesis make it a valuable compound for creating novel therapeutics that could potentially offer better efficacy and fewer side effects than existing treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 1205548-00-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,5,5,4 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1205548-00:
(9*1)+(8*2)+(7*0)+(6*5)+(5*5)+(4*4)+(3*8)+(2*0)+(1*0)=120
120 % 10 = 0
So 1205548-00-0 is a valid CAS Registry Number.

1205548-00-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4'-DMA-7,8-DHF*HBr

1.2 Other means of identification

Product number -
Other names 2-(4-(dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1205548-00-0 SDS

1205548-00-0Downstream Products

1205548-00-0Relevant articles and documents

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect

Liu, Xia,Chan, Chi-Bun,Jang, Sung-Wuk,Pradoldej, Sompol,Huang, Junjian,He, Kunyan,Phun, Lien H.,France, Stefan,Xiao, Ge,Jia, Yonghui,Luo, Hongbo R.,Ye, Keqiang

experimental part, p. 8274 - 8286 (2011/02/23)

7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural-activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential for the agonistic effect. To improv

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