121-04-0

Basic information

• Product Name: toluene-2,4-disulphonic acid
• Synonyms: toluene-2,4-disulphonic acid;4-Methyl-1,3-benzenedisulfonic acid
• CAS NO: 121-04-0
• Molecular Formula: C₇H₈O₆S₂
• Molecular Weight: 252.26482
• EINECS: 204-446-9
• Mol File: 121-04-0.mol

Chemical Properties

• Melting Point: 295-297 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.667g/cm³
• Refractive Index: 1.604
• PKA: -1.06±0.45(Predicted)
• CAS DataBase Reference: toluene-2,4-disulphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-2,4-disulphonic acid(121-04-0)
• EPA Substance Registry System: toluene-2,4-disulphonic acid(121-04-0)

Safety Data

• Hazardous Substances Data: 121-04-0(Hazardous Substances Data)

Usage

Uses

Used in Dye and Pigment Production:
Toluene-2,4-disulphonic acid is utilized as a key intermediate in the synthesis of dyes and pigments, contributing to the coloration and stability of these products.
Used in Organic Synthesis:
It serves as a source of the sulfonate functional group in various organic synthesis processes, enhancing the reactivity and properties of the resulting compounds.
Used as a Catalyst in Chemical Reactions:
Due to its strong acidic nature, toluene-2,4-disulphonic acid is employed as a catalyst to facilitate and speed up numerous chemical reactions, improving the efficiency of industrial processes.
Used in Pharmaceutical Production:
Toluene-2,4-disulphonic acid is used as an intermediate in the manufacturing of pharmaceuticals, playing a crucial role in the development of new drugs and medicines.
Used in Agrochemical Production:
It is also an intermediate in the production of agrochemicals, contributing to the effectiveness of these products in agricultural applications.
Used in Specialty Chemicals:
Toluene-2,4-disulphonic acid finds use in the creation of specialty chemicals for specific industries, leveraging its unique properties to meet particular needs.
Handling and Storage:
Due to its acidic and corrosive properties, toluene-2,4-disulphonic acid requires careful handling and storage to ensure safety and prevent damage to equipment and the environment.

InChI:InChI=1/C7H8O6S2/c1-5-2-3-6(14(8,9)10)4-7(5)15(11,12)13/h2-4H,1H3,(H,8,9,10)(H,11,12,13)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 108-88-3 toluene 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 624-31-7 4-tolyl iodide 
• 2767-77-3 toluene-2,4-disulfonyl dichloride 
• 7790-94-5 chlorosulfonic acid 
• 7664-93-9 sulfuric acid 
• 88-20-0 o-toluenesulfonic acid 
• 618-03-1 3-amino-4-methylbenzenesulfonic acid 
• 118-88-7 4-amino-toluene-2-sulfonic acid 
• 504433-96-9 toluene-2,4-disulfinic acid 
• 7732-18-5 water 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 3347-99-7 4-methyl isophthalic acid 
• 496-73-1 4-methyl resorcinol 
• 88-39-1 4-formyl-1,3-benzenedisulfonic acid 
• 51084-25-4 2,4-disulfobenzoic acid 
• 103-69-5 N-ethyl-N-phenylamine 
• 854637-15-3 2,4-bis-benzenesulfonyl-toluene 
• 69-72-7 salicylic acid 
• 99-96-7 4-hydroxy-benzoic acid 

Relevant articles and documents

Kinetics of hydrolysis of aromatic mono- and disulfonyl chlorides

A continuous polarografic method of recording instantaneous concentrations of - SO2Cl groups in an aqueous acetic acid system containing CH3CO2Na has been elaborated.Ten model monosulfonyl chlorides underwent hydrolysis according to pseudo-first order kinetics (20percent H2O, 80percent v.v.CH3CO2H, 0.5 mol/dm3 CH3CO2Na).Plots of hydrolysis for seven disulfonyl dichlorides with different number of - CH3 groups have been determined.Pseudo-first order rate constants for two consecutive reactions of hydrolysis (k1 and k2) have been computed and the influence of -SO2Cl and -SO3- groups on the reactivity of the second group - SO2Cl has been discussed.The mechanism of nucleophilic substitution has also been discussed.

Aromatic sulfonation 85. Halogen directing and steric effects in the sulfonation of the twelve halogenotoluenes and some related compounds

The isomer distributions for the sulfonation of the twelve halogenotoluenes and some trisubstituted halogenomethylbenzenes, with both 98.4 percent H2SO4 at 25 deg C and sulfur trioxide in nitromethane at 0 deg C, have been determined and found to be very similar.The predominantly para-directing effect of the halogen substituent dominates over that of the methyl substituent: with the 2-halogenotoluenes, the degree of 5-substitution decreases from >/= 90 percent for the fluoro to 50 percent for the iodo compound.The 2- to 3-sulfonation ratio of the 4-halogenotoluenes strongly increases on going from fluorine (0.5) to iodine (7).The ratio of the partial rate factors for the sulfonation of a halogenobenzene ortho and meta to halogen varies from 17 +/- 1 for the fluoro to 1.5 +/- 0.4 for the iodo substituent.In competition to the sulfonation, 2- and 4-iodotoluene undergo deiodination, The latter process is more important with the 4-isomer and with the protic sulfonating reagent.With the aprotic reagent, the reaction proceeds by direct sulfodeiodination, whereas with the sulfuric acid reagent, it proceeds by initial protiodeiodination and sulfodeprotonation.