121-48-2

Basic information

• Product Name: 3,5-disulphobenzoic acid
• Synonyms: 3,5-disulphobenzoic acid;3,5-disulfo-benzoic aci;3,5-Disulfobenzoic acid
• CAS NO: 121-48-2
• Molecular Formula: C₇H₆O₈S₂
• Molecular Weight: 282.24774
• EINECS: 204-474-1
• Mol File: 121-48-2.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.913g/cm³
• Refractive Index: 1.648
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 3,5-disulphobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-disulphobenzoic acid(121-48-2)
• EPA Substance Registry System: 3,5-disulphobenzoic acid(121-48-2)

Safety Data

• Hazardous Substances Data: 121-48-2(Hazardous Substances Data)

Usage

Uses

3,5-Disulfobenzoic Acid?is used in preparation of Dihydroxybenzoic Acid.

InChI:InChI=1/C7H6O8S2/c8-7(9)4-1-5(16(10,11)12)3-6(2-4)17(13,14)15/h1-3H,(H,8,9)(H,10,11,12)(H,13,14,15)

Upstream product

• 65-85-0 benzoic acid 
• 7664-93-9 sulfuric acid 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 4142-98-7 ethyl 3,5-dihydroxybenzoate 
• 14206-69-0 3-amino-5-hydroxybenzoic acid hydrochloride 
• 121-91-5 isophthalic acid 

Relevant articles and documents

Biosynthesis of tetrapetalones

The biosynthesis of tetrapetalones (tetrapetalones A, B, C, and D) in Streptomyces sp. USF-4727 was studied by feeding experiments with 1- 13C sodium propanoate, 1-13C sodium butanoate, carbonyl-13C 3-amino-5-hydroxybenzoic acid (AHBA) hydrochloride, and 1-13C glucose, followed by analysis of the 13C-NMR spectra. These feeding experiments revealed that the four tetrapetalones were polyketide compounds constructed from propanoate, butanoate, AHBA, and glucose. The tetrapetalone biosynthetic pathway was also suggested in this study. In this pathway, tetrapetalone A (1) is synthesized by polyketide synthase (PKS) using AHBA as a starter unit, then the side chain of 1 is subjected to acetoxylation to produce tetrapetalone B (2). Additionally, 1 is oxidized and transformed into tetrapetalone C (3). In a similar way, 2 is converted to tetrapetalone D (4). Therefore, the biosynthetic relationship of the four tetrapetalones was indicated. This journal is The Royal Society of Chemistry.

MODIFIED BIOTIN-BINDING PROTEINS FOR IMMOBILIZATION

Compositions comprising covalently modified and mutated biotin-binding proteins, particularly biotin-binding proteins having a negative charge at physiological pH, are provided. Methods of producing such proteins are also provided, as are methods of immobilizing, sequencing, and making nucleic acids employing such proteins.

PROCESS FOR PREPARING SUBSTITUTED AROMATIC CARBOXYLIC ACIDS

A process for preparing an aromatic carboxylic acid having a heteroatom containing substituent is provided that includes reaction in a vessel of an aromatic precursor having an aromatic core with at least one heteroatom containing substituent and at least one hydrogen extending from the core, with a haloacetonitrile under reaction conditions to form an aromatic acetonitrile with an acetonitrile moiety. The aromatic acetonitrile is exposed to an oxidizing agent under conditions to convert the acetonitrile moiety to a carboxylic acid group to prepare the aromatic carboxylic acid having the heteroatom containing substituent.

The positional reactivity order in the sulfur trioxide sulfonation of benzene and naphtalene derivatives containing an electron-withdrawing substituent

The reaction of sulfur trioxide with derivatives of benzene and naphthalene containing an electron-withdrawing substituent, viz.-SO3H, -SO2Ph, -NO2, -CHO, -COPh, -CO2H, and -CO2Me, in dichloromethane as solvent at ca. 22 deg C has been studied by analysis of the resulting mixtures of the sulfo derivatives with 1H-NMR.The initial sulfonation of the benzene derivatives yields the corresponding 3-sulfonic acid (3-S) and subsequently, with the exception of nitrobenzene and methyl benzoate, small amounts of 3,5-S2.Benzenesulfonic acid in addition undergoes sulfonylation giving 3,3'-di- and 3,5,3'-trisulfodiphenyl sulfone.Monosulfonation of naphtalene-1-S yields the 1,5-S2, 1,6-S2 and 1,7-S2 derivatives in a ratio of 71:20:9.On using a large excess of SO3, the eventual products are 1,3,5-S3, 1,3,6-S3 and 1,3,5,7-S4.Monosulfonation of naphthalene yields 5-S, 6-S, 7-S and 8-S in a 55:9:6:30 ratio, that of 1-benzoylnaphthalene 5-S, 6-S and 7-S in a ratio of 83:11:6, and 1-nitronaphtalene only the 5-S.The absence of peri sulfonation with 1-sulfo-, 1-benzoyl- and 1-nitronaphthalene is due to prohibitive steric hidrance. 1-Naphthoic acid and its methyl ester upon SO3 sulfonation and aqueous work-up both yield 5- and 8-sulfonaphthoic acid in a ratio of 65:35 and 77:21, respectively.The initially formed peri-substituted product is the intramolecular anhydride of 8-sulfo-1-naphthoic acid (5).All the 2-substituted naphthalenes yield 5-S and 8-S upon SO3 sulfonation of which the former sulfo isomer is far in excess.The positional reactivity orders for the SO3 sulfonation of the monosubstituted naphthalene derivatives are discussed in terms of the difference in reactivity of the α- and β-positions, and the steric and electronic effects of the deactivating substituent.