1217853-93-4 Usage
Uses
Used in Pharmaceutical Industry:
(S)-BM 14686 is used as an active pharmaceutical ingredient for the development of medications targeting beta-adrenergic receptors. Its alpha-1 blocking activity contributes to its therapeutic effects in treating cardiovascular conditions.
Used in Research and Development:
(S)-BM 14686 is used as a research compound for studying the mechanisms of action and potential applications of beta-blockers in various diseases and conditions. Its optically active nature allows for investigations into stereoselectivity and enantioselectivity in drug interactions and effects.
Used in Drug Metabolism Studies:
(S)-BM 14686 is used as a metabolite in drug metabolism studies to understand the biotransformation processes of Carvedilol and its impact on the drug's efficacy and safety profile. This information can be valuable for optimizing drug formulations and dosing regimens.
Used in Quality Control and Analytical Testing:
(S)-BM 14686 is used as a reference standard in quality control and analytical testing to ensure the purity, potency, and consistency of Carvedilol-containing pharmaceutical products. This helps maintain the safety and efficacy of medications for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1217853-93-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,8,5 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1217853-93:
(9*1)+(8*2)+(7*1)+(6*7)+(5*8)+(4*5)+(3*3)+(2*9)+(1*3)=164
164 % 10 = 4
So 1217853-93-4 is a valid CAS Registry Number.
1217853-93-4Relevant articles and documents
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol
Malig, Thomas,Xiao, Zhichao,Chen, S.R. Wayne,Back, Thomas G.
, p. 149 - 153 (2015/12/18)
Carvedilol is a drug widely used in the treatment of heart failure and associated cardiac arrhythmias. A unique action of carvedilol is its suppression of store overload-induced calcium release (SOICR) through the cardiac ryanodine receptor (RyR2), which can trigger ventricular arrhythmias. Since the effects of carvedilol metabolites on SOICR have not yet been investigated, three carvedilol metabolites hydroxylated at the 3-, 4′ and 5′-positions were synthesized and assayed for SOICR inhibition in mutant HEK 293 cells expressing the RyR2 mutant R4496C. This cell line is especially prone to SOICR and calcium release through the defective RyR2 channel was measured with a calcium-sensitive fluorescent dye. These results revealed that the 3- and 4′-hydroxy derivatives are slightly more effective than carvedilol in suppressing SOICR, while the 5′-analog proved slightly less active. Metabolic deactivation of carvedilol via these hydroxylation pathways is therefore insignificant.
Synthesis of active metabolites of carvedilol, an antihypertensive drug
Senthilkumar,Somannavar,Reddy, Shankar B.,Sinha, Brajesh Kumar,Narayan,Dandala, Ramesh,Mukkanti, Kaga
, p. 268 - 276 (2011/03/20)
A simple synthetic route for active metabolites of carvedilol is reported. The metabolites 4'-hydroxycarvedilol and 5'-hydroxycarvedilol have exhibited high activity for -blockade. We have disclosed syntheses of 4'-hydroxycarvedilol and 5'-hydroxycarvedil
