122293-95-2Relevant articles and documents
Chiral ethyl [6-amino-4-[[12-(methoxymethylamino)-1-methyl-2-oxoethyl]amino]-5-nitro-2-pyridyl]carbamate
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, (2008/06/13)
The present invention relates to compounds of the formula STR1 wherein each of R and R1 is a lower alkyl group having from 1 to 4 carbon atoms, which are useful as intermediates to make chiral ethyl (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[
New Anticancer Agents: Chiral Isomers of Ethyl 5-Amino-1,2-dihydro-2-methyl-3-phenylpyridopyrazine-7-carbamate
Temple, Carroll,Rener, Gregory
, p. 2089 - 2092 (2007/10/02)
Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyridopyrazine-7-carbamate (1a) has shown antitumor activity in a variety of in vivo experiments.The preparation of the R (9) and S (10) isomers gave compounds with significant differences in potency in several biological tests.
'(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazin-7-yl)-carbamic acid, ethyl ester
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, (2008/06/13)
The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)arbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(±)- racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells. The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.
1,2-Dihydropyrido[3,4-b]pyrazines: Structure-activity relationships
Temple Jr.,Wheeler,Elliott,Rose,Comber,Montgomery
, p. 91 - 95 (2007/10/02)
Certain derivatives containing the 1,2-dihydropyrido[3,4-b]pyrazine (1-deaza-7,8-dihydropteridine) ring system are active against experimental neoplasms in mice. The mechanism of action of these agents has r539w1 =4-amino-1-deaza-7,8-dihydro-6-[(N-methyla