1238895-96-9

Basic information

• Product Name: acetonitrile-(1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N₂,N₃')-dichlorido-cobalt(II)
• CAS NO: 1238895-96-9
• Molecular Weight: 536.364
• Mol File: 1238895-96-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetonitrile-(1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N₂,N₃')-dichlorido-cobalt(II)(CAS DataBase Reference)
• NIST Chemistry Reference: acetonitrile-(1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N₂,N₃')-dichlorido-cobalt(II)(1238895-96-9)
• EPA Substance Registry System: acetonitrile-(1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N₂,N₃')-dichlorido-cobalt(II)(1238895-96-9)

Safety Data

• Hazardous Substances Data: 1238895-96-9(Hazardous Substances Data)

Upstream product

• 1238895-90-3 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N₂,N₃'-dichlorido-cobalt(II) 
• 75-05-8 acetonitrile 

Relevant articles and documents

Synthesis, X-ray structures, electrochemical properties and cytotoxic effects of Co(II) complexes

1-Benzothiazol-2-yl-3,5-dimethyl-1H-pyrazole (1a) and 1-benzothiazol-2-yl- 5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1b) were reacted with the hexahydrates of cobalt(II) chloride, cobalt(II) nitrate and cobalt(II) perchlorate to give the corresponding complexes 2a-4a and 2b-5b, respectively. Obtained compounds differ in coordination spheres of central atoms. The complex 2a includes a fivefold coordinated cobalt(II) ion, whereas 3a shows a distorted octahedral configuration around the cobalt(II) ion. All complexes were characterised by FTIR spectroscopy, MS and elemental analysis. The X-ray structures of 2a, 3a and 5b complexes were also solved. The cytotoxic properties of the ligand 1a and both series of Co(II) complexes were examined on human leukemia NALM-6 and HL-60 cells and melanoma WM-115 cells. The ligands, were found to have very low cytotoxicity. Complex 3b exhibited the highest cytotoxic activity with IC50 values in the range of 6.9-17.1 μM for three examined cell lines.