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1256963-02-6

LEE011, also known as ribociclib, is a CDK4/6 inhibitor that has been approved by the FDA under the brand name Kisqali. It is used in combination with an aromatase inhibitor for initial endocrine-based therapy in the treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. LEE011 works by inhibiting the growth of tumor cells by arresting them at the G1 checkpoint, preventing their proliferation.

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  • 1256963-02-6 Structure

  • Basic information

    1. Product Name: LEE011
    2. Synonyms: LEE011;CDK4/6 inhibitor;CDK4 inhibitor;CDK4-IN-1;Ribociclib;4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;Ribociclib(LEE011);Ribociclib(Lee011 & CDK 4/6 inhibitor)
    3. CAS NO:1256963-02-6
    4. Molecular Formula: C22H29ClN8
    5. Molecular Weight: 440.97226
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 1256963-02-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 679.3±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.31±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO (Slightly), Methanol (Slightly)
    9. PKA: 7.57±0.50(Predicted)
    10. CAS DataBase Reference: LEE011(CAS DataBase Reference)
    11. NIST Chemistry Reference: LEE011(1256963-02-6)
    12. EPA Substance Registry System: LEE011(1256963-02-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1256963-02-6(Hazardous Substances Data)

1256963-02-6 Usage

Uses

Used in Pharmaceutical Industry:
LEE011 is used as a CDK 4/6 inhibitor for the treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It is combined with an aromatase inhibitor for initial endocrine-based therapy, demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis.

References

S. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02. Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco ?2014. https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment

Check Digit Verification of cas no

The CAS Registry Mumber 1256963-02-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,9,6 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1256963-02:
(9*1)+(8*2)+(7*5)+(6*6)+(5*9)+(4*6)+(3*3)+(2*0)+(1*2)=176
176 % 10 = 6
So 1256963-02-6 is a valid CAS Registry Number.

1256963-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine

1.2 Other means of identification

Product number -
Other names 4-(5-chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1256963-02-6 SDS

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