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1262059-05-1

1-(2-bromoethoxy)-2-isopropoxybenzene is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1262059-05-1 Structure

  • Basic information

    1. Product Name: 1-(2-bromoethoxy)-2-isopropoxybenzene
    2. Synonyms: 1-(2-bromoethoxy)-2-isopropoxybenzene
    3. CAS NO:1262059-05-1
    4. Molecular Formula:
    5. Molecular Weight: 259.143
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1262059-05-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(2-bromoethoxy)-2-isopropoxybenzene(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(2-bromoethoxy)-2-isopropoxybenzene(1262059-05-1)
    11. EPA Substance Registry System: 1-(2-bromoethoxy)-2-isopropoxybenzene(1262059-05-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1262059-05-1(Hazardous Substances Data)

1262059-05-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1262059-05-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,0,5 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1262059-05:
(9*1)+(8*2)+(7*6)+(6*2)+(5*0)+(4*5)+(3*9)+(2*0)+(1*5)=131
131 % 10 = 1
So 1262059-05-1 is a valid CAS Registry Number.

1262059-05-1Relevant articles and documents

Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties

Canale, Vittorio,Kurczab, Rafa,Partyka, Anna,Sataa, Grzegorz,Ledna, Tomasz,Jastrzebska-Wiesek, Magdalena,Wesoowska, Anna,Bojarski, Andrzej J.,Zajdel, Pawel

supporting information, p. 334 - 346 (2015/12/23)

A series of 39 arylsulfonamide/amide derivatives of (aryloxy)ethyl alkyl amines, was designed with the support of the Virtual Combinatorial Library-Virtual Screening protocol, and synthesized using solidphase methodologies. Representative compounds were biologically evaluated for their affinity for 5-HT7Rs and for their selectivity over related 5-HTRs (5-HT1ARs, 5-HT2ARs, 5-HT6Rs), dopamine D2Rs and adrenergic a1Rs. The study identified the derivatives 27 (3-fluoro-N-{1-[2-(2-cyclopentylphenoxy) ethyl]piperidin-4-yl}-benzenesulfonamide; PZ-1417) and 35 (4-fluoro-N-(1-{2-[(propan-2-yl)phenoxy] ethyl}-8-azabicyclo[3.2.1]octan-3-yl)-benzenesulfonamide; PZ-1150) as being potent 5-HT7R antagonists with antidepressant and anxiolytic properties in the forced swim test (0.625e5 mg/kg and 0.625 mg/kg, respectively), the tail suspension test (0.625 mg/kg and 0.625 mg/kg, respectively), and in four plate test (0.625 mg/kg and 1.25e2.5 mg/kg, respectively) in mice. It has to be stressed that new compounds displayed higher activity than that of SB-269970, a reference 5-HT7R antagonist. Finally, the study provided valuable insight into the development of potential therapeutic agents for the treatment of CNS disorders.

Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity

Rak, Aleksandra,Canale, Vittorio,Marciniec, Krzysztof,?mudzki, Pawe?,Kotańska, Magdalena,Knutelska, Joanna,Siwek, Agata,Stachowicz, Gabriela,Bednarski, Marek,Nowiński, Leszek,Zygmunt, Ma?gorzata,Zajdel, Pawe?,Sapa, Jacek

, p. 5582 - 5591 (2016/10/22)

A series of arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines was synthesized to develop new α1-adrenoceptor antagonists with uroselective profile. Biological evaluation for α1- and α2-adrenorecepo

Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues

Sagratini, Gianni,Angeli, Piero,Buccioni, Michela,Gulini, Ugo,Marucci, Gabriella,Melchiorre, Carlo,Poggesi, Elena,Giardin, Dario

experimental part, p. 5800 - 5807 (2011/02/26)

Tamsulosin (-)-1 is the most utilized α1-adrenoceptor antagonist in the benign prostatic hyperplasia therapy owing to its uroselective antagonism and capability in relieving both obstructive and irritative lower urinary tract symptoms. Here we report the synthesis and pharmacological study of the homochiral (-)-1 analogues (-)-2-(-)-5, bearing definite modifications in the 2-substituted phenoxyethylamino group in order to evaluate their influence on the affinity profile for α1-adrenoceptor subtypes. The benzyl analogue (-)-3, displaying a preferential antagonist profile for α1A-than α1D-and α1B- adrenoceptors, and a 12-fold higher potency at α1A- adrenoceptors with respect to the α1B subtype, may have improved uroselectivity compared to (-)-1.

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