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(1-methyl-1H-indol-2-yl)acetic acid, also known as indoleacetic acid, is an organic compound with the chemical formula C11H11NO2. It is a derivative of indole, a heterocyclic aromatic organic compound, and features a methyl group attached to the nitrogen atom and an acetic acid group at the 2-position. (1-methyl-1H-indol-2-yl)acetic acid is known for its potential biological activity and has been studied for its effects on various biological processes.

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  • 127019-98-1 Structure
  • Basic information

    1. Product Name: (1-methyl-1H-indol-2-yl)acetic acid
    2. Synonyms: (1-methyl-1H-indol-2-yl)acetic acid;2-(1-Methyl-1H-indol-2-yl)acetic acid
    3. CAS NO:127019-98-1
    4. Molecular Formula: C11H11NO2
    5. Molecular Weight: 189
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 127019-98-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: (1-methyl-1H-indol-2-yl)acetic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1-methyl-1H-indol-2-yl)acetic acid(127019-98-1)
    11. EPA Substance Registry System: (1-methyl-1H-indol-2-yl)acetic acid(127019-98-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127019-98-1(Hazardous Substances Data)

127019-98-1 Usage

Uses

Used in Pharmaceutical Industry:
(1-methyl-1H-indol-2-yl)acetic acid is used as a pharmaceutical agent for targeting kidney glutaminase allosteric sites. It serves as an inhibitor that can modulate the activity of kidney glutaminase, an enzyme involved in the metabolism of glutamine to glutamate, which is crucial for various cellular processes, including energy production and the synthesis of nucleotides and proteins. By targeting this enzyme, (1-methyl-1H-indol-2-yl)acetic acid may have therapeutic applications in conditions where the regulation of glutaminase activity is beneficial, such as in the treatment of certain types of cancer that rely on glutamine metabolism for growth and survival.

Check Digit Verification of cas no

The CAS Registry Mumber 127019-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,0,1 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127019-98:
(8*1)+(7*2)+(6*7)+(5*0)+(4*1)+(3*9)+(2*9)+(1*8)=121
121 % 10 = 1
So 127019-98-1 is a valid CAS Registry Number.

127019-98-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1-methylindol-2-yl)acetic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127019-98-1 SDS

127019-98-1Relevant articles and documents

General Method for the Synthesis of Bridged Indole Alkaloids. Nucleophilic Addition of Indoleacetic Ester Enolates to N-Alkylpyridinium Salts

Bennasar, M.-Lluisa,Alvarez, Mercedes,Lavilla, Rodolfo,Zulaica, Ester,Bosch, Joan

, p. 1156 - 1168 (2007/10/02)

A short route to tetracyclic ring substructures of C-mavacurine, Strychnos, and akuammiline-type alkaloids, based on the addition of methyl 1-, 2-, or 3-indoleacetate anions to N-alkylpyridinium salts followed by acid cyclization of the resultant 1,4-dihydropyridines, is reported.Further stereoselective elaboration of the C-20 (E)-ethylidene substituent results in the synthesis of the indole alkaloid vinoxine (7b) and of 4-ethylidene-hexahydro-1,5-methanoazocino- and -indoles 14-17, 32, and 35.Some mechanistic aspects concerning the regiochemistry of the nucleophilic addition to the pyridinium ring are discussed.

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