127019-98-1 Usage
Uses
Used in Pharmaceutical Industry:
(1-methyl-1H-indol-2-yl)acetic acid is used as a pharmaceutical agent for targeting kidney glutaminase allosteric sites. It serves as an inhibitor that can modulate the activity of kidney glutaminase, an enzyme involved in the metabolism of glutamine to glutamate, which is crucial for various cellular processes, including energy production and the synthesis of nucleotides and proteins. By targeting this enzyme, (1-methyl-1H-indol-2-yl)acetic acid may have therapeutic applications in conditions where the regulation of glutaminase activity is beneficial, such as in the treatment of certain types of cancer that rely on glutamine metabolism for growth and survival.
Check Digit Verification of cas no
The CAS Registry Mumber 127019-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,0,1 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127019-98:
(8*1)+(7*2)+(6*7)+(5*0)+(4*1)+(3*9)+(2*9)+(1*8)=121
121 % 10 = 1
So 127019-98-1 is a valid CAS Registry Number.
127019-98-1Relevant articles and documents
General Method for the Synthesis of Bridged Indole Alkaloids. Nucleophilic Addition of Indoleacetic Ester Enolates to N-Alkylpyridinium Salts
Bennasar, M.-Lluisa,Alvarez, Mercedes,Lavilla, Rodolfo,Zulaica, Ester,Bosch, Joan
, p. 1156 - 1168 (2007/10/02)
A short route to tetracyclic ring substructures of C-mavacurine, Strychnos, and akuammiline-type alkaloids, based on the addition of methyl 1-, 2-, or 3-indoleacetate anions to N-alkylpyridinium salts followed by acid cyclization of the resultant 1,4-dihydropyridines, is reported.Further stereoselective elaboration of the C-20 (E)-ethylidene substituent results in the synthesis of the indole alkaloid vinoxine (7b) and of 4-ethylidene-hexahydro-1,5-methanoazocino- and -indoles 14-17, 32, and 35.Some mechanistic aspects concerning the regiochemistry of the nucleophilic addition to the pyridinium ring are discussed.
