16498-68-3Relevant academic research and scientific papers
One-Pot Assembly of 3-Hydroxycarbazoles via Uninterrupted Propargylation/Hydroxylative Benzannulation Reactions
Reddy, Chada Raji,Subbarao, Muppidi,Sathish, Puppala,Kolgave, Dattahari H.,Donthiri, Ramachandra Reddy
supporting information, p. 689 - 693 (2020/01/31)
A novel strategy for the synthesis of 3-hydroxycarbazoles involving the consecutive propargylation/palladium-catalyzed hydroxylative benzannulation of indole-2-carbonyls with propargylic alcohols has been exploited. This one-pot procedure leads to a wide range of substituted 3-hydroxycarbazoles in high yield with a broad substrate scope. The method was further extended to access furano-carbazole derivatives from dialkynols via tandem annulations.
Beta-carboline derivatives, gamma-carboline derivatives as well as preparation methods and use thereof
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Paragraph 0085; 0092, (2017/08/29)
The invention relates to beta-carboline derivatives, gamma-carboline derivatives as well as preparation methods and use thereof. The general structural formulas of the beta-carboline derivatives and the gamma-carboline derivatives are respectively describ
Design, synthesis, and biological activity of oxime ether strobilurin derivatives containing indole moiety as novel fungicide
Xie, Ya-Qiang,Huang, Zi-Long,Yan, Hui-Dong,Li, Jun,Ye, Li-Yi,Che, Li-Ming,Tu, Song
, p. 743 - 755 (2015/05/27)
Twenty-one novel oxime ether strobilurins containing indole moiety, which employed an indole group to stabilize the E-styryl group in Enoxastrobin, were designed and synthesized. The biological assay indicated that most compounds exhibited potent fungicidal activities. The structure-activity relationship study demonstrated that the synthesized methyl 3-methoxypropenoate oxime ethers 7b-e exhibited remarkably high activities among all the synthesized oxime ether compounds 7. Moreover, the fungicidal activities of methyl α-(methoxyimino)benzeneacetate oxime ethers compounds 7f-i and N-methoxy-carbamic acid methyl esters compounds 7j-m showed significant differences compared to the corresponding products of ammonolysis.
Synthesis of highly substituted indene derivatives by Br?nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols
Zhang, Xiaoxiang,Teo, Wan Teng,Rao, Weidong,Ma, Dik-Lung,Leung, Chung-Hang,Chan, Philip Wai Hong
, p. 3881 - 3884 (2014/07/08)
An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Br?nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.
Design and synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors
Sechi, Mario,Derudas, Massimiliano,Dallocchio, Roberto,Dessì, Alessandro,Bacchi, Alessia,Sannia, Luciano,Carta, Fabrizio,Palomba, Michele,Ragab, Omar,Chan, Carney,Shoemaker, Robert,Sei, Shizuko,Dayam, Raveendra,Neamati, Nouri
, p. 5298 - 5310 (2007/10/03)
Diketo acids such as S-1360 (1A) and L-731,988 (2) are potent and selective inhibitors of HIV-1 integrase (IN). A plethora of diketo acid-containing compounds have been claimed in patent literature without disclosing much biological activities and synthetic details (reviewed in Neamati, N. Exp. Opin. Ther. Pat. 2002, 12, 709-724). To establish a coherent structure - activity relationship among the substituted indole nucleus bearing a β-diketo acid moiety, a series of substituted indole-β-diketo acids (4a-f and 5a-e) were synthesized. All compounds tested showed anti-IN activity at low micromolar concentrations with varied selectivity against the strand transfer process. Three compounds, the indole-3-β-diketo acids 5a and 5c, and the parent ester 9c, have shown an antiviral activity in cell-based assays. We further confirmed a keto-enolic structure in the 2,3-position of the diketo acid moiety of a representative compound (4c) using NMR and X-ray crystallographic analysis. Using this structure as a lead for all of our computational studies, we found that the title compounds extensively interact with the essential amino acids on the active site of IN.
Preparations and Reactions of 2-Cyanoindole Derivatives
Lin, Chih-Da,Fang, Jim-Min
, p. 571 - 580 (2007/10/02)
2-Cyano-1-phenylsulfonylindole (1a) and 2-cyano-1-methylindole (1b) were prepared by chemical and electrolytic methods in modest yields.Nucleophiles such as sodium benzenethiolate, butyllithium and lithium dimethylcuprate attacked the sulfonyl group of 1a, whereas they attacked the cyano group of 1b. 1,3-Dipolar cycloadditions of 1a and 1b with 2,4,6-trimethylbenzonitrile oxide occurred at the cyano groups.Electrophilic reactions of 1b with N-bromosuccinimide, Vilsmeir reagent and acetyl chloride afforded the corresponding 3-bromo-, 3-formyl- and 3-acetylindole derivatives in modest or high yields, albeit less rapidly than the reactions of 1-methylindole.Photochemical addition of dimethyl acetylenedicarboxylate to 1b was followed by cleavage of the cyclobutene intermediate to give dimethyl (2-cyano-1-methylbenzazepine)-3,4-dicarboxylate. Key Words Cyanoindoles; Electrophilic reactions; Nucleophilic reactions; Diels-Alder reactions; 1,3-Dipolar cycloadditions; Photochemistry.
Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
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, (2008/06/13)
Compounds of the formula: STR1 wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2 R3, wherein R2 and R3 are independently selected from (1) hydrogen, (2) C1 to C4 alkyl and (3) hydroxyl, but R2 and R3 are not simultaneously hydroxyl; wherein X is oxygen, sulfur, SO2, or NR4, wherein R4 is (1) hydrogen, (2) C1 to C6 alkyl, (3) C1 to C6 alkoyl, (4) aroyl, or (5) alkylsulfonyl; A is selected from C1 to C6 alkylene and C2 to C6 alkenylene; n is 1-5; Y is selected independently at each occurrence from (1) hydrogen, (2) halogen, (3) hydroxy, (4) cyano, (5) halosubstituted alkyl, (6) C1 to C12 alkyl, (7) C2 to C12 alkenyl, (8) C1 to C12 alkoxy, (9) C3 to C8 cycloalkyl, (10) C1 -C8 thioalkyl, (11) aryl, (12) aryloxy, (13) aroyl, (14) C1 to C12 arylalkyl, (15) C2 to C12 arylalkenyl, (16) C1 to C12 arylalkoxy, (17) C1 to C12 arylthioalkoxy, and substituted derivatives of (18) aryl, (19) aryloxy, (20) aroyl, (21) C1 to C12 arylalkyl, (22) C2 to C12 arylalkenyl, (23) C1 to C12 arylalkoxy, or (24) C1 to C12 arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C1 to C12 alkyl, alkoxy, and halosubstituted alkyl; Z is oxygen or sulfur; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C1 to C12 alkoyl, are potent inhibitors of 5- and/or 12-lipoxygenase enzymes. Also disclosed are lipoxygenase inhibiting compositions and a method for inhibiting lipoxygenase activity.
TANDEM ORGANOMETALLIC ADDITION REACTIONS TO N-METHOXY-UREAS AND URETHANES IN THE PREPARATION OF UNSYMMETRICAL AND SYMMETRICAL KETONES
Hlasta, Dennis J.,Court, John J.
, p. 1773 - 1776 (2007/10/02)
The use of novel reagents 1a-c for the synthesis of ketones in a one pot reaction is described.An interesting leaving group effect was discovered in the fragmentation of the proposed complexes 2 to the intermediate N-methoxyamides 3.
