127132-38-1Relevant articles and documents
Divergent and site-selective solid-phase synthesis of sulfopeptides
Taleski, Deni,Butler, Stephen J.,Stone, Martin J.,Payne, Richard J.
, p. 1316 - 1320 (2011)
On solid ground: A solid-phase strategy for the efficient synthesis of sulfopeptides is described. Selective deprotection of orthogonally-protected tyrosine residues and solid-phase sulfation provided divergent access to differentially sulfated peptides in high yields. Copyright
Macrocyclic analogues of the diuretic insect neuropeptide helicokinin I show strong receptor-binding
Tran Van, Chien,Nennstiel, Dirk,Scherkenbeck, Jürgen
, p. 3278 - 3286 (2015)
Abstract Helicokinin I, a diuretic neuropeptide of the relevant cotton pest Helicoverpa zea represents a promising target for the design of insect neuropeptide mimetics. Using a ring-closing metathesis reaction, N-terminal bridged macrocyclic helicokinin
Chiral Lewis acids supported on silica gel and alumina, and their use as catalysts in Diels-Alder reactions of methacrolein and bromoacrolein
Fraile, Jose M.,Garcia, Jose I.,Mayoral, Jose A.,Royo, Ana J.
, p. 2263 - 2276 (1996)
Several derivatives of (S)-tyrosine are supported on silica gel through the phenolic oxygen atom. The Lewis acids obtained by treatment of these solids with BH3 are able to promote the reactions of methacrolein and bromoacrolein with cyclopenta
Polymer Attached Cyclic Dipeptides as Catalysts for Enantioselective Cyanohydrin Formation
Kim, Hyun J.,Jackson, W. Roy
, p. 1421 - 1430 (1992)
Derivatives of cyclo-, related to the "Inoue" catalyst, cyclo- have been attached to chloromethylated polystyrene and to polysiloxane polymers via spacer groups coupled to the tyrosine phenolic residue.These polymer-attac
Total Synthesis of the Putative Structure of Asperipin-2a and Stereochemical Reassignment
Hutton, Craig A.,Shabani, Sadegh,White, Jonathan M.
supporting information, p. 7730 - 7734 (2020/10/09)
The total synthesis of the putative structure of asperipin-2a is described. The synthesis features ether cross-links between the phenolic oxygen of Tyr6 and the β position of Tyr3 and the phenolic oxygen of Tyr3 and the β position of Hpp1 in the unique 17- and 14-membered bicyclic structure of asperipin-2a, respectively. The synthesized putative structure does not match the natural product, and a stereochemical reassignment is postulated.
Design and synthesis of β-strand-fixed peptides inhibiting aggregation of amyloid β-protein
Akagi, Ken-ichi,Masuda, Yuichi,Monobe, Yoko,Shibata, Kana,Tanaka, Fumiya
supporting information, (2020/08/07)
Aggregation of 42-residue amyloid β-protein (Aβ42) can be prevented by β-sheet breaker peptides (BSBps) homologous to LVFFA residues, which are included in a β-sheet region of Aβ42 aggregates. To enhance the affinity of BSBps to the Aβ42 aggregates, we de
Novel non-peptide GPIIb/IIIa antagonists: Synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2- oxoethyl)-2-oxopiperazinyl] acetic acids
Kitamura,Fukushi,Miyawaki,Kawamura,Terashita,Sugihara,Naka
, p. 258 - 267 (2007/10/03)
To improve the in vitro and in vivo potency of our first low molecular weight GPIIb/IIIa antagonist 1 (TAK-029), a series of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2- oxoethyl)-2-oxopiperazinyl]acetic acids were synthesized th
A4 B6 macrotricyclic enantioselective receptors for amino acid derivatives, and other compounds
-
, (2008/06/13)
The subject invention provides chiral receptor molecules having the structure: STR1 wherein A has the structure: STR2 and R1 and R2 are independently the same or different and are H, F, alkyl, aryl, etc.; X is CH2 or NH; Y is C=O or SO2 ; and n is 0 to about 3; which are useful for the purification of enantiomers of amino acid derivatives and other compounds. The subject invention also provides methods of preparing said receptor molecules.
Enantioselective receptor for amino acid derivatives, and other compounds
-
, (2008/06/13)
The present invention relates to a composition having the general formula: STR1 wherein each of A, B, C, X, Y, and Z is independently O, NH, N(CH2)m CH3 ], N(C=O) (CH2)m CH3 ], CH2, S, or Se; each of R1, R2, and R3 is independently phenyl, 4-hydroxyphenyl, pyridyl, pyrrolyl, indolyl, naphthyl, thiophenyl, (C=O) (CH2)p CH3, NH(C=O) (CH2)p CH3 ], OH, COOH, NH2, or SH; and m, n, and p are integers between 0 and 5. The composition is a chiral receptor molecule useful for the purification of enantiomers of derivatives of amino acids and of compounds able to form hydrogen bonds. The preparation of the composition involves coupling a trifunctional aromatic molecule with three protected chiral molecules at the three aromatic groups, cleaving protecting groups, and joining adjacent chiral groups by multiple lactamizations. The receptor may be used in a form either bound to a solid support or dissolved in an immiscible phase to effect convenient purification of enantiomers or other compounds of interest.
Reductive deprotection of aryl allyl ethers with Pd(Ph3)4/NaBH4
Beugelmans, Rene,Bourdet, Sebastien,Bigot, Antony,Zhu, Jieping
, p. 4349 - 4350 (2007/10/02)
Treatment of aryl allyl ethers with catalytic amounts of Pd(PPh3)4 and NaBH4 at room temperature afforded the parent phenol in high yield under non-hydrolytic conditions.