138535-28-1Relevant articles and documents
Synthetic studies towards Pseudoxylallemycin B, an antibiotic active against gram-negative bacteria: Total synthesis of 3-epi-Pseudoxylallemycin B
Gunjal, Vidya B.,Reddy, D. Srinivasa
, p. 2900 - 2903 (2018)
In an attempt towards the total synthesis of Pseudoxylallemycin B, a homo dimeric, N-methylated macrocyclic tetrapeptidic natural product, synthesis of its epimer at position 3 (D-Tyr instead of L-Tyr) is described here. During the course of synthesis we came across a striking yet unusual observation of complete epimerization which led to the formation of 3-epi-Pseudoxylallemycin B.
New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities
Boyle, Timothy P.,Bremner, John B.,Coates, Jonathan,Deadman, John,Keller, Paul A.,Pyne, Stephen G.,Rhodes, David I.
experimental part, p. 11270 - 11290 (2009/04/06)
As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as potential novel anti-bacterial agents, we explored the synthesis of simple tyrosine-based systems. These were prepared via key intermediates containing internal allylglycine and allyltyrosine residues for subsequent ring-closing metathesis reactions. Although the resulting anti-bacterial activity against Staphylococcus aureus was modest, this represents a novel and simple route to this class of compounds. One intermediate acyclic dipeptide precursor showed good activity against S. aureus with an MIC of 7.8 μg/mL. Crown Copyright
