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128564-66-9

5-Bromo-1-(triisopropylsilyl)-1H-indole is a complex indole derivative, a heterocyclic aromatic organic compound with a bicyclic structure that combines a benzene ring with a pyrrole ring. The presence of a triisopropylsilyl group serves as a silyl protecting agent, crucial in organic synthesis to shield reactive sites, while the bromine substitution offers a reactive site for further functionalization. 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE is significant in medicinal chemistry as it can act as a key precursor in the synthesis of various natural and synthetic compounds.

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  • 128564-66-9 Structure

  • Basic information

    1. Product Name: 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE
    2. Synonyms: 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE;5-bromo-1-[tris(propan-2-yl)silyl]-1h-indole
    3. CAS NO:128564-66-9
    4. Molecular Formula: C17H26BrNSi
    5. Molecular Weight: 352.38
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 128564-66-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 180 °C
    3. Flash Point: 159.3°C
    4. Appearance: /
    5. Density: 1.14g/cm3
    6. Vapor Pressure: 8.99E-05mmHg at 25°C
    7. Refractive Index: 1.534
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE(128564-66-9)
    12. EPA Substance Registry System: 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE(128564-66-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 128564-66-9(Hazardous Substances Data)

128564-66-9 Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1-(triisopropylsilyl)-1H-indole is used as a key precursor for the synthesis of various pharmaceutical compounds, due to its potential to be further functionalized and incorporated into complex molecular structures.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Bromo-1-(triisopropylsilyl)-1H-indole is used as a protected intermediate, where the triisopropylsilyl group protects the indole core from unwanted reactions until the desired transformations are achieved.
Used in Medicinal Chemistry Research:
5-Bromo-1-(triisopropylsilyl)-1H-indole is utilized as a starting material in the development of new drugs, given its potential to exhibit interesting biological activities that can be explored through further research and development.
Used in Chemical Modification:
5-Bromo-1-(triisopropylsilyl)-1H-indole is employed in the modification of other chemical compounds, where the bromine atom can be replaced with other functional groups to create new derivatives with altered properties and potential applications.

Check Digit Verification of cas no

The CAS Registry Mumber 128564-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,5,6 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128564-66:
(8*1)+(7*2)+(6*8)+(5*5)+(4*6)+(3*4)+(2*6)+(1*6)=149
149 % 10 = 9
So 128564-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H26BrNSi/c1-12(2)20(13(3)4,14(5)6)19-10-9-15-11-16(18)7-8-17(15)19/h7-14H,1-6H3

128564-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-bromoindol-1-yl)-tri(propan-2-yl)silane

1.2 Other means of identification

Product number -
Other names 5-bromo-1-tri(1-methyl)ethylsilylindole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128564-66-9 SDS

128564-66-9Relevant articles and documents

PYRROLO-PYRIDINE DERIVATIVES

-

, (2008/06/13)

Compounds of formula I are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia. STR1 wherein Q is STR2

The synthesis and pharmacological evaluation of indole congeners of the calcium entry blocker verapamil

Soll, Richard M.,Parks, James A.,Rimele, Thomas J.,Heaslip, Richard J.,Wojdan, Alexandra,et al.

, p. 191 - 196 (2007/10/02)

Based on the notion of a bioisosteric relationship between catechol-(phenol-) and indole-amines, indole congeners of the calcium entry blocker verapamil were synthesized and examined as calcium entry blockers and as alpha1-adrenoceptor antagonists in isolated tissue preparations and as antihypertensive agents in the spontaneously hypertensive rat.Indole 27 exhibited potent calcium entry blockade in vitro and displayed antihypertensive activity, albeit slightly less than verapamil.Indole 23 possessed both calcium entry blockade and potent alpha1-adrenoceptor activity in vitro but in vivo was less active than verapamil as an antihypertensive agent.

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