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13050-47-0

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13050-47-0 Usage

Description

3-Methyl-benzoylhydrazide, also known as N'-methyl-3-oxobenzohydrazide, is a chemical compound characterized by the molecular formula C9H10N2O2. It presents as a white to yellow crystalline solid and serves as a versatile reagent in organic synthesis and a pharmaceutical intermediate. 3-Methyl-benzoylhydrazide is recognized for its potential applications across various fields, including medicine, agriculture, and materials science, with its antimicrobial and antifungal properties highlighting its bioactivity.

Uses

Used in Pharmaceutical Industry:
3-Methyl-benzoylhydrazide is used as a pharmaceutical intermediate for the synthesis of various drugs, leveraging its reactivity and structural properties to facilitate the creation of new medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methyl-benzoylhydrazide is utilized as a key component in the production of pesticides and herbicides, contributing to the development of effective crop protection agents.
Used as a Dye Intermediate:
3-Methyl-benzoylhydrazide is employed as a dye intermediate, playing a crucial role in the synthesis of dyes used in various applications, including textiles and other industrial processes.
Used in Polymer Industry:
As a stabilizer in polymers, 3-Methyl-benzoylhydrazide helps to enhance the stability and performance of polymeric materials, extending their durability and resistance to degradation.
Used in Materials Science:
3-Methyl-benzoylhydrazide's potential in materials science is attributed to its ability to contribute to the development of new materials with improved properties, such as enhanced stability and reactivity.
Used in Antimicrobial and Anti-Fungal Applications:
3-Methyl-benzoylhydrazide is studied for its antimicrobial and antifungal properties, indicating its potential as a bioactive agent in various applications, including medical and environmental uses.

Check Digit Verification of cas no

The CAS Registry Mumber 13050-47-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,5 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13050-47:
(7*1)+(6*3)+(5*0)+(4*5)+(3*0)+(2*4)+(1*7)=60
60 % 10 = 0
So 13050-47-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O/c1-6-3-2-4-7(5-6)8(11)10-9/h2-5H,9H2,1H3,(H,10,11)

13050-47-0 Well-known Company Product Price

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  • Alfa Aesar

  • (L01043)  m-Toluic hydrazide, 97%   

  • 13050-47-0

  • 5g

  • 365.0CNY

  • Detail
  • Alfa Aesar

  • (L01043)  m-Toluic hydrazide, 97%   

  • 13050-47-0

  • 25g

  • 1310.0CNY

  • Detail

13050-47-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methyl-Benzoylhydrazide

1.2 Other means of identification

Product number -
Other names 3-methylbenzohydrazide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13050-47-0 SDS

13050-47-0Relevant articles and documents

Synthesis, crystal structures and insulin-like activity of three new oxidovanadium(V) complexes with aroylhydrazone ligand

Zhou, Quan-Cheng,Wang, Tian-Rui,Li, Hui,Chen, Lei,Xin, Jia-Jin,Guo, Shen,Sheng, Gui-Hua,You, Zhong-Lu

, (2019)

Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental analysis, single crystal X-ray diffraction,UV/Vis and IR spectra. Complex 1: [VOL1X] (H2L1 = (E)-N′-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL2(CH3O)(CH3OH)], (H2L2 = C16H16N2O4 = (E)-N′-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CH3OH = methanol), Complex 3: [VOL3X] (H2L3 = (E)-N′-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Both normal and streptozotocin (STZ)-diabetic mice were administered intragastrically for two weeks. It was found that the complexes at doses of 10.0 and 5.0 mg V·kg?1 can significantly decrease the blood glucose level in STZ-diabetic mice, and the blood glucose level in the treated normal mice was not altered. The lesions of kidney and liver caused by diabetes have varying degrees of improvement.

Oxazole ring-containing honokiol thioether derivative and preparation method and application thereof

-

Paragraph 0042; 0045-0046, (2021/08/11)

The invention discloses an oxazole ring-containing honokiol thioether derivative, a preparation method thereof and application of the oxazole ring-containing honokiol thioether derivative as an alpha-glucosidase inhibitor, the chemical structure of the oxazole ring-containing honokiol thioether derivative is shown as a general formula (I), and R is selected from non-substituted or substituted phenyl. Compared with the prior art, the invention provides the novel honokiol thioether derivative containing the oxazole ring, and the honokiol thioether derivative containing the oxazole ring has good inhibitory activity on alpha-glucosidase, provides more possibilities for treating diabetes, and is expected to be used for preparing novel candidate drug molecules for treating diabetes. In addition, the preparation process is simple, the cost is low, and the yield is high.

Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker

Liu, Jie,Zhang, Guang-Yu,Zhang, Zhe,Li, Bo,Chai, Fei,Wang, Qi,Zhou, Zi-Dan,Xu, Ling-Ling,Wang, Shou-Kai,Jin, Zhen,Tang, You-Zhi

, (2021/05/17)

A class of pleuromutilin derivatives containing 1, 3, 4-oxadiazole were designed and synthesized as potential antibacterial agents against Methicillin-resistant staphylococcus aureus (MRSA). The ultrasound-assisted reaction was proposed as a green chemistry method to synthesize 1, 3, 4-oxadiazole derivatives (intermediates 85–110). Among these pleuromutilin derivatives, compound 133 was found to be the strongest antibacterial derivative against MRSA (MIC = 0.125 μg/mL). Furthermore, the result of the time-kill curves displayed that compound 133 could inhibit the growth of MRSA in vitro quickly (- 4.36 log10 CFU/mL reduction). Then, compound 133 (- 1.82 log10 CFU/mL) displayed superior in vivo antibacterial efficacy than tiamulin (- 0.82 log10 CFU/mL) in reducing MRSA load in mice thigh model. Besides, compound 133 exhibited low cytotoxicity to RAW 264.7 cells. Molecular docking studies revealed that compound 133 was successfully localized in the binding pocket of 50S ribosomal subunit (ΔGb = -10.50 kcal/mol). The results indicated that these pleuromutilin derivatives containing 1, 3, 4-oxadiazole might be further developed into novel antibiotics against MRSA.

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