59646-36-5

Upstream product

• 13050-47-0 3-methylbenzoyl hydrazine 
• 1711-06-4 3-Methylbenzoyl chloride 
• 202273-27-6 C₁₇H₁₈N₄O₃ 

Downstream Products

• 17452-91-4 2,5-di(m-tolyl)-1,3,4-thiadiazole 
• 91913-87-0 3,3'-(1,3,4-thiadiazole-2,5-diyl)dibenzoic acid 
• 2425-96-9 diethyl 3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoate 
• 2425-93-6 3,3'-(1,3,4-oxadiazole-2,5-diyl)dibenzoic acid 
• 59646-37-6 2,5-bis(3-methylphenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

Oxidation of Hydrazides Using Sodium Perborate: Formation of N,N′-Diacylhydrazines

Substituted aromatic hydrazides react very smoothly with sodium perborate in glacial acetic acid at room temperature to give N,N′-diacylhydrazines in excellent yields and purity.

Polyphosphoric acid and anhydrous aluminium chloride catalysed novel rearrangements of 1,5-diaroylcarbohydrazides

1,5-Diaroylcarbohydrazides 1 on reaction with polyphosphoric acid (PPA) at 150 deg C for 15 min undergo an interesting rearrangement to afford 2,5-diaryl-1,3,4-oxadiazoles 2. However, the reaction of 1 with anhydrous aluminium chloride yields 1,2-diaroylhydrazines 3.

The Synthesis Of (1,3,4-Oxadiazole-2,5-Diyl) Dibenzoic Acids and Their Thiadiazole Analogues

The title compounds are best prepared by oxidation of the corresponding 2,5-ditolyl-1,3-4-oxadiazole or -thiadiazole, and are most easily characterised by the 13C n.m.r. spectra of their di-potassium salts.

Oxidation of Hydrazine Derivatives with Arylsulfonyl Peroxides

A new method for the generation of the azo function is reported.A series of hydrazine derivatives, which included alkyl- and arylhydrazines, monoacylhydrazides, and diacylhydrazides, was oxidized with m-(trifluoromethyl)benzenesulfonyl peroxide.Smooth conversion to the diimide was observed.The diimides then yielded products typical of normal degradation pathways.