1315336-92-5

Basic information

• Product Name: 2-phenylquinazolin-4-yl 4-methylbenzenesulfonate
• Synonyms: 2-phenylquinazolin-4-yl 4-methylbenzenesulfonate
• CAS NO: 1315336-92-5
• Molecular Weight: 376.436
• Mol File: 1315336-92-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-phenylquinazolin-4-yl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylquinazolin-4-yl 4-methylbenzenesulfonate(1315336-92-5)
• EPA Substance Registry System: 2-phenylquinazolin-4-yl 4-methylbenzenesulfonate(1315336-92-5)

Safety Data

• Hazardous Substances Data: 1315336-92-5(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1022-45-3 2-phenyl-4-hydroxy quinazoline 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 

Downstream Products

• 1315337-02-0 4-(perfluorophenyl)-2-phenylquinazoline 
• 1382529-47-6 4-(2-chlorophenylsulfanyl)-2-phenylquinazoline 
• 1382529-45-4 4-(4-fluorophenylsulfanyl)-2-phenylquinazoline 
• 1382529-49-8 4-butylsulfanyl-2-phenylquinazoline 
• 910611-48-2 2-phenyl-4-phenylsulfanylquinazoline 
• 1174014-13-1 2-phenyl-4-p-tolylsulfanylquinazoline 
• 1382529-48-7 4-benzylsulfanyl-2-phenylquinazoline 
• 1382529-46-5 4-(4-chlorophenylsulfanyl)-2-phenylquinazoline 
• 1229609-91-9 4-(4-fluoro-phenyl)-2-phenyl-quinazoline 
• 16107-82-7 4-(4-methylphenyl)-2-phenyl-quinazoline 
• 31730-65-1 2,4-diphenylquinazoline 
• 1229609-97-5 4-cyclopentyl-2-phenylquinazoline 
• 1229609-96-4 4-cyclopropyl-2-phenyl-quinazoline 
• 68674-67-9 4-ethyl-2-phenylquinazoline 

Relevant articles and documents

Palladium-Catalyzed Cross-Coupling of 4-Tosyloxyquinazolines with Organoindium Reagents: An Efficient Route to 4-Substituted Quinazolines

An efficient route to 4-substituted quinazolines by arylation or alkylation of quinazolinones under mild conditions is described. 4-Tosyloxyquinazolines were obtained through the reaction of quinazolinones and p-methylbenzenesulfonyl chloride in the presence of K2CO3. The cross-coupling reaction of 4-tosyloxyquinazolines with organoindium reagents, carried out in tetrahydrofuran, catalyzed by Pd2(dba)3/ (2-furyl)3P led to the formation of 4-functionalized quinazolines in good to excellent yields. Higher yields were obtained by the one-pot reaction of quinazolinone, p-methylbenzenesulfonyl chloride, Pd2(dba)3-/(2-furyl)3P, and organoindium reagent. These methods using organoindium compounds as coupling partners provided an efficient route to 4-(hetero)aryl/alkylquinazolines, especially 4-substituted quinazolines bearing a halogen scaffold.

Direct sulfanylation of 4-quinazolinone via c-oh bond activation: An efficient route to 2-aryl-4-sulfanylquinazolines

The direct sulfanylation of 2-aryl-4-quinazolinones with thiols via C-OH bond activation under mild conditions is described. The method affords the corresponding 2-aryl-4-sulfanylquinazolines in good to excellent yield. Georg Thieme Verlag Stuttgart - New