31730-65-1

Usage

Uses

Used in Pharmaceutical Industry:
2,4-diphenylquinazoline is used as a starting material for the synthesis of various pharmaceuticals, leveraging its chemical properties to develop new drugs for the treatment of medical conditions such as cancer and cardiovascular diseases. Its role in drug development is crucial due to its potential to be modified and incorporated into a range of therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 2,4-diphenylquinazoline is utilized as a precursor in the synthesis of various agrochemicals, contributing to the development of products designed to improve crop protection and yield.
Used in Materials Science:
In the field of materials science, 2,4-diphenylquinazoline is explored for its potential application in the development of organic electronic devices. Its unique properties make it a candidate for use in advancing the performance and capabilities of these devices.

Upstream product

• 100-47-0 benzonitrile 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 52143-11-0 1,4-dihydro-1,3,6-triphenyl-s-tetrazine 
• 108-86-1 bromobenzene 
• 125743-39-7 2-<(benzylidene)amino>benzonitrile 
• 107288-89-1 2,4-diphenyl-1,2-dihydroquinazoline 
• 98-88-4 benzoyl chloride 
• 1885-29-6 anthranilic acid nitrile 
• 123622-08-2 1-(Isopropoxy-phenyl-methyl)-1H-benzotriazole 
• 13909-34-7 N-benzylidenephenylsulfonamide 
• 23879-26-7 1-phenyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene 
• 201024-81-9 C,N-diphenylnitrone 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1229610-02-9 2-(2-methylphenyl)-4-phenyl-quinazoline 

Relevant academic research and scientific papers

Heterogeneous selective synthesis of 1,2-dihydro-1,3,5-triazines from alcohols and amidines via Cu/OMS-2-catalyzed multistep oxidation

Copper supported on octahedral manganese oxide molecular sieve (OMS-2) which was obtained via reducing KMnO4 by TBHP was prepared and found to be an efficient catalyst for the synthesis of 1,2-dihydro-1,3,5-triazines directly from alcohols and amidines in one-pot via multistep oxidation. The recyclable heterogeneous catalyst was characterized by BET, XRD, FTIR, TEM and SEM, and the catalytic system can tolerate a wide range of substrates under air with low catalyst loading of supported copper (0.25?mol%), employing OMS-2 as the electron-transfer mediator (ETM) and support.

Tropylium-promoted Ritter reactions

The Ritter reaction used to be one of the most powerful synthetic tools to functionalize alcohols and nitriles, providing valuableN-alkyl amide products. However, this reaction has not been frequently used in modern organic synthesis due to its employment of strongly acidic and harsh reaction conditions, which often lead to complicated side reactions. Herein, we report the development of a new method using salts of the tropylium ion to promote the Ritter reaction. This method works well on a range of alcohol and nitrile substrates, giving the corresponding products in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction

Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.

STK19 INHIBITORS FOR TREATMENT OF CANCER

Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma.

Sulfur-Mediated Decarboxylative Coupling of 2-Nitrobenzyl Alcohols and Arylacetic Acids

We report a new method for the synthesis of substituted quinazolines by the condensation of 2-nitrobenzyl alcohols with arylacetic acids. The transformation requires the use of urea as a nitrogen source, elemental sulfur as a promoter, DABCO as a base, and DMSO as a solvent. Functionalities such as chloro, fluoro, trifluoromethyl, thienyl, and indolyl groups were all compatible with the reaction conditions. Because our method uses stable simple substrates to obtain the N,N-heterocycles in the absence of transition metals, it offers a potential pathway for preparing complex structures under mild conditions.

Visible-Light-Induced Benzylic C-H Functionalization for the Synthesis of 2-Arylquinazolines

This work reports a mild and efficient approach for the synthesis of substituted quinazolines using 1-(2-aminoaryl)ethan-1-ones in conjunction with arylmethanamines as starting materials via visible-light-induced benzylic C–H functionalization. The reaction proceeded at room temperature with low catalyst loading and the reaction system was clean from beginning to end. Significantly, this method exhibited good tolerance even to free hydroxyl group and amino group contained in substrates.

Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines

An efficient synthesis of quinazolines based on an iron-catalyzed C(sp3)-H oxidation and intramolecular C-N bond formation using tert-BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N-H ketimine species. The FeCl2-catalyzed C(sp3)-H oxidation of the alkyl group employing tert-BuOOH followed by intramolecular C-N bond formation and aromatization afforded a wide variety of 2,4-disubstituted quinazolines in good to excellent yields.

Synthesizing method of drug intermediate quinazoline compound

The invention relates to a quinazoline compound as shown in formula (5) and capable of being used as a drug intermediate and a synthesizing method of the quinazoline compound. The synthesizing methodhas the advantages that the method is completed through

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha