31730-65-1

Basic information

• Product Name: 2,4-diphenylquinazoline
• Synonyms: 2,4-Diphenylquinazoline; 2,4-Diphenyl-quinazoline; quinazoline, 2,4-diphenyl-
• CAS NO: 31730-65-1
• Molecular Formula: C₂₀H₁₄N₂
• Molecular Weight: 282.3386
• Mol File: 31730-65-1.mol
• Article Data: 72

Chemical Properties

• Boiling Point: 373.5°C at 760 mmHg
• Flash Point: 166.4°C
• Density: 1.173g/cm³
• Vapor Pressure: 1.92E-05mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 2,4-diphenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diphenylquinazoline(31730-65-1)
• EPA Substance Registry System: 2,4-diphenylquinazoline(31730-65-1)

Safety Data

• Hazardous Substances Data: 31730-65-1(Hazardous Substances Data)

Usage

General Description

2,4-diphenylquinazoline is a chemical compound with the molecular formula C20H14N2. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. 2,4-diphenylquinazoline belongs to the quinazoline class of organic compounds and is used as a starting material for the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential use in the development of new drugs for the treatment of various medical conditions, including cancer and cardiovascular diseases. Additionally, 2,4-diphenylquinazoline has also been investigated for its potential application in the field of materials science, particularly in the development of organic electronic devices.

Upstream product

• 40288-69-5 N-(2-cyanophenyl)benzamide 
• 14677-96-4 3,5,5-triphenyl-4,5-dihydro-1,2,4-oxadiazole 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 591-50-4 iodobenzene 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 100-52-7 benzaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 98-80-6 phenylboronic acid 
• 98-88-4 benzoyl chloride 
• 107288-89-1 2,4-diphenyl-1,2-dihydroquinazoline 
• 108-86-1 bromobenzene 
• 125743-39-7 2-<(benzylidene)amino>benzonitrile 
• 52143-11-0 1,4-dihydro-1,3,6-triphenyl-s-tetrazine 
• 100-47-0 benzonitrile 

Downstream Products

• 1229610-02-9 2-(2-methylphenyl)-4-phenyl-quinazoline 

Relevant articles and documents

Heterogeneous selective synthesis of 1,2-dihydro-1,3,5-triazines from alcohols and amidines via Cu/OMS-2-catalyzed multistep oxidation

Copper supported on octahedral manganese oxide molecular sieve (OMS-2) which was obtained via reducing KMnO4 by TBHP was prepared and found to be an efficient catalyst for the synthesis of 1,2-dihydro-1,3,5-triazines directly from alcohols and amidines in one-pot via multistep oxidation. The recyclable heterogeneous catalyst was characterized by BET, XRD, FTIR, TEM and SEM, and the catalytic system can tolerate a wide range of substrates under air with low catalyst loading of supported copper (0.25?mol%), employing OMS-2 as the electron-transfer mediator (ETM) and support.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

Sulfur-Mediated Decarboxylative Coupling of 2-Nitrobenzyl Alcohols and Arylacetic Acids

We report a new method for the synthesis of substituted quinazolines by the condensation of 2-nitrobenzyl alcohols with arylacetic acids. The transformation requires the use of urea as a nitrogen source, elemental sulfur as a promoter, DABCO as a base, and DMSO as a solvent. Functionalities such as chloro, fluoro, trifluoromethyl, thienyl, and indolyl groups were all compatible with the reaction conditions. Because our method uses stable simple substrates to obtain the N,N-heterocycles in the absence of transition metals, it offers a potential pathway for preparing complex structures under mild conditions.