13170-66-6Relevant articles and documents
Direction of the Dipole Moment in the Ester Group
Salz, E.,Hummel, J. P.,Flory, P. J.,Plavslc, M.
, p. 3211 - 3215 (1981)
The directions of the dipole moments in esters RCOOR' in which R and R' are alkyl or aryl groups have been deduced by analysis of experimental values of dipole moments of six compounds containing two polar groups, one or both of which are esters.New determinations of molecular dipole moments are reported for dimethyl trans-1,4-cyclohexanedicarboxylate and for trans-1,4-cyclohexanediol diacetate.The moment of the ester group is directed (in the positive sense) at an angle τE=123 +/- 3 deg from the R-CO axis in both aromatic and aliphatic esters, formates excepted.
Method for preparing 1, 4-diphenyl cyclohexanedicarboxylate
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Paragraph 0012; 0039-0050; 0051; 0063; 0075; 0087-0093, (2018/03/26)
The invention belongs to the field of chemical synthesis and specifically relates to a method for preparing 1, 4-diphenyl cyclohexanedicarboxylate. The method comprises the following steps: performinga reaction in a solvent under the action of a catalyst
POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
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Paragraph 0169-0170, (2018/04/21)
PROBLEM TO BE SOLVED: To provide a polymerizable compound which has high storage stability and can form a film-like polymer while being difficult to cause alignment defects, where the film-like polymer is less likely to be separated from a substrate even when irradiated with ultraviolet for a long time. SOLUTION: The invention provides a compound represented by general formula (I), and a polymer thereof. A composition comprising the compound is useful as a polymerizable liquid crystal composition. (For example, the compound is bis[4-(acryloyloxyethoxy-ethoxy-ethoxy)phenyl]1,4-cyclohexanedicarboxylate.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
Novel bivalent securinine mimetics as topoisomerase I inhibitors
Hou, Wen,Lin, Hui,Wang, Zhen-Ya,Banwell, Martin G.,Zeng, Ting,Sun, Ping-Hua,Lin, Jing,Chen, Wei-Min
, p. 320 - 328 (2017/03/08)
A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.