134303-96-1 Usage
Uses
Used in Peptide Synthesis:
FMOC-PRO-PRO-PRO-OH is utilized as a building block in the synthesis of peptides, particularly in solid-phase peptide synthesis. Its role is to extend the peptide chain, providing a foundation for the creation of more complex and biologically active molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, FMOC-PRO-PRO-PRO-OH is employed as a precursor in the development of new drugs. Its conformational properties and the presence of proline residues may contribute to the compound's potential therapeutic effects, making it a valuable asset in the discovery and design of novel pharmaceutical agents.
Used in Chemical Research:
FMOC-PRO-PRO-PRO-OH is also used in chemical research as a model compound to study the properties of peptides and their interactions with other molecules. This can lead to a better understanding of peptide behavior and the development of new chemical methodologies.
Used in Biochemical Studies:
In biochemical research, FMOC-PRO-PRO-PRO-OH serves as a tool to investigate the mechanisms of peptide folding, stability, and interactions with biological targets. Its use can provide insights into protein structure and function, which are essential for understanding various biological processes and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 134303-96-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,0 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 134303-96:
(8*1)+(7*3)+(6*4)+(5*3)+(4*0)+(3*3)+(2*9)+(1*6)=101
101 % 10 = 1
So 134303-96-1 is a valid CAS Registry Number.
134303-96-1Relevant articles and documents
Hybrid bombesin analogues: Combining an agonist and an antagonist in defined distances for optimized tumor targeting
Kroll, Carsten,Mansi, Rosalba,Braun, Friederike,Dobitz, Stefanie,Maecke, Helmut R.,Wennemers, Helma
, p. 16793 - 16796 (2013)
Radiolabeled hybrid ligands with defined distances between an agonist and an antagonist for the gastrin-releasing peptide receptor were found to have excellent tumor-targeting properties. Oligoprolines served as rigid scaffolds that allowed for tailoring distances of 10, 20, and 30 A between the recognition elements. In vitro and in vivo studies revealed that the hybrid ligand with a distance of 20 A between the recognition elements exhibits the highest yet observed tumor cell uptake and retention time in prostate cancer cells.
An improved preparation of a tertiary alcohol proline linker and its use in a synthesis of mosquito oostatic hormone
Kochansky,Wagner
, p. 8007 - 8010 (2007/10/02)
An improved synthesis of 4-(3'-hydroxy-3'-methylbutyl)phenoxyacetic acid was developed using THF to overcome solubility problems initially encountered in trying to reproduce the published preparation. This hydroxyacid linker was coupled to aminomethyl polystyrene resin and used for a synthesis of the mosquito oostatic hormone by the Fmoc protocol. Attempts to prepare this insect peptide by other techniques had failed because of loss of cyclo-Pro2 from the resin.
