1344-48-5Relevant articles and documents
Tetrahydropteridines for treatment of neurological disorders
-
, (2008/06/13)
Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric and neurological disorders are disclosed.
Metal-containing steroid mimics and ligands useful in the preparation thereof
-
, (2008/06/13)
Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions are also provided. The metal ion is preferably a radionucl
Esters of mercapto acyl-carnitines and pharmaceutical compositions containing same
-
, (2008/06/13)
A novel class of esters of mercapto acyl-carnitines is disclosed, wherein the mercapto acyl radical is the radical of saturated mercapto acids having from 2 to 10 carbon atoms. These esters of mercapto acyl-carnitines are prepared e.g. by first preparing
Alcohol derivatives
-
, (2008/06/13)
This invention relates to alcohol derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: STR1 in which R1 and R2, same or different, are hydrogen or 1-10C alkyl, 3-8C cycloalkyl or 4-14C cycloalkylalkyl, each alkyl, cycloalkyl or cycloalkylalkyl optionally carrying one or more F, Cl or Br atoms, provided that one of R1 and R2 is halogen-substituted, or R2 is hydrogen and R1 is R5 --E--W-- in which W is 2-6C alkylene optionally substituted by 1 or 2 1-4C alkyl, E is O, S, SO, SO2 or NR6 in which R6 is H or 1-6C alkyl, R5 is H or 1-6C alkyl optionally substituted by 1 or 2 1-4C alkyls, or R5 and R6 are joined to form a pyrrolidine, piperidine, morpholine, piperazine or N-methylpiperazine ring, or R2 is hydrogen and R1 is hydrogen or 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C arylalkyl or 7-11C aroyl, the aryl, arylalkyl and aroyl radicals being optionally substituted, ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene or a 1-8C alkylene into which is optionally inserted one or two groups; D is oxygen or sulphur; R3, R4 and R5 are hydrogen or a variety of radicals described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.
Long-lasting agonists of enkephalin
-
, (2008/06/13)
Novel peptides of the formula: STR1 wherein X is S or (CH2)n and n is 0, 1 or 2, and R1 through R6 are various amino acid and other substituents; having long-lasting enkephalin agonist activity; useful in treati
1-Substituted-2-(substituted-imino)-1H-1,2-dihydrobenz[cd]indoles
-
, (2008/06/13)
Novel 1-substituted-2-(substitutedimino)-1H-1,2-dihydrobenz[cd]indoles useful as inhibitors of platelet aggregation.
2-(4-Methoxyoxazolidinone-4-yl)thiazolidine t-butyl esters
-
, (2008/06/13)
6-acylamido-6-methoxypenicillanic acids are obtained by reacting a 6-acylamidopenicillanic acid with mercuric acetate in methanol to yield a methyl α-methoxypenicilloate. Esterification of the latter with isobutylene affords the methyl, t-butyl diester of the methoxypenicilloic acid which undergoes selective hydrolysis in base to provide the free α-carboxylic acid half t-butyl ester of the penicilloic acid. The latter on reaction with dicyclohexylcarbodiimide affords an oxazolone-thiazolidine of the formula STR1 WHICH WITH 98% FORMIC ACID PROVIDES A COMPOUND OF THE INVENTION.
Certain 3-furyl sulfides
-
, (2008/06/13)
Novel 3-sulfur derivatives of furan including alkyl furan-3-thiols and bis(alkyl-3-furyl) sulfides and di- and tetrahydro derivatives thereof having meaty and/or roasted aromas and flavors; processes for producing such 3-sulfur derivatives; novel flavoring compositions containing such derivatives; and novel food compositions containing such derivatives.
3-(P-methoxybenzylthio)2-non-oxocarbonylic pyridines
-
, (2008/06/13)
3-Thiolpicolinic acid is prepared by reacting a 3-halopyridine, having a 2-substituent which is hydrolyzable to a carboxy group, with an alkali metal salt of p-methoxybenzyl mercaptan, hydrolyzing the 2-substituent to a carboxy group and then cleaving the