1345730-92-8

Basic information

• Product Name: 12-N-p-methylbenzyl matrinic acid
• Synonyms: 12-N-p-methylbenzyl matrinic acid
• CAS NO: 1345730-92-8
• Molecular Weight: 370.535
• Mol File: 1345730-92-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 12-N-p-methylbenzyl matrinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 12-N-p-methylbenzyl matrinic acid(1345730-92-8)
• EPA Substance Registry System: 12-N-p-methylbenzyl matrinic acid(1345730-92-8)

Safety Data

• Hazardous Substances Data: 1345730-92-8(Hazardous Substances Data)

Upstream product

• 104-82-5 4-Methylbenzyl chloride 
• 109616-04-8 C₁₆H₂₈N₂O₂ 
• 519-08-4 matrinic acid 
• 519-02-8 (+)-matrine 

Relevant articles and documents

Natural-product-based pesticides: Semisynthesis, structural elucidation, and evaluation of new cholesterol–matrine conjugates as pesticidal agents

To develop new potential pesticide candidates from low value-added natural bioactive products, a series of new cholesterol–matrine conjugates (I(a–e)–IV(a–e)) were prepared from two lead compounds cholesterol and matrine. Against Mythimna separata Walker, compound IVa exhibited 3.0 and 2.6 folds promising insecticidal activity of cholesterol and matrine, respectively; against Aphis citricola Van der Goot, compound IVd showed 4.3 and 2.2 folds potent aphicidal activity of their precursors; notably, it also showed good control effects in the greenhouse; against Plutella xylostella Linnaeus at a dose of 20 μg/nymph, compound IIIe exhibited 2.8 and 2.0 folds oral toxicity of cholesterol and matrine, respectively. Compounds IIIe, IVd and IVe can be used as the leads for further structural optimization as the insecticidal and aphicidal agents.

Synthesis of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold as insecticidal/acaricidal agents

In continuation of our program aimed at the development of natural product-based pesticidal agents, a series of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold were prepared, and their insecticidal and acaricidal activities were evaluated against Mythimna separata and Tetranychus cinnabarinus. Some compounds exhibited potent insecticidal and acaricidal activities. It suggested that R1 as a nitro group and R2 as a fluorine atom, were important for the insecticidal activity; R1 as the electron-donating groups and R2 as the methyl group, were necessary for the acaricidal activity.

Semisynthesis of Matrinic Acid/Alcohol/Ester Derivatives, Their Pesticidal Activities, and Investigation of Mechanisms of Action against Tetranychus cinnabarinus

To discover new natural-product-based potential pesticides, 85 matrinic acid/alcohol/ester derivatives were synthesized by structural modifications of a quinolizidine alkaloid matrine. N-(4-Methyl)benzylmatrinyl n-decylate (76) and N-(2-chloro)benzylmatri