1345731-58-9Relevant articles and documents
Discovery of potent selective orally active benzoxazepine-based orexin-2 receptor antagonists
Fujimoto, Tatsuhiko,Kunitomo, Jun,Tomata, Yoshihide,Marui, Shogo,Nishiyama, Keiji,Nakashima, Masato,Yoshikubo, Shin-Ichi,Hirai, Keisuke,Hirozane, Mariko
, p. 6414 - 6416 (2011/11/29)
During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett rp and Hansch-Fu