1350760-48-3Relevant articles and documents
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists
Liu, Weiguo,Hussain, Zahid,Zang, Yi,Sweis, Ramzi F.,Romero, F. Anthony,Finke, Paul E.,Moningka, Remond,Bao, Jianming,Plotkin, Michael A.,Shang, Jin,Dingley, Karen H.,Salituro, Gino,Murphy, Beth Ann,Howard, Andrew D.,Ujjainwalla, Feroze,Wood, Harold B.,Duffy, Joseph L.
supporting information, p. 1088 - 1093 (2018/10/24)
A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed imp