135299-35-3

Basic information

• Product Name: ethyl 3-keto-5-methyl-2-hexanoate
• CAS NO: 135299-35-3
• Molecular Weight: 321.441
• Mol File: 135299-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-keto-5-methyl-2-hexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-keto-5-methyl-2-hexanoate(135299-35-3)
• EPA Substance Registry System: ethyl 3-keto-5-methyl-2-hexanoate(135299-35-3)

Safety Data

• Hazardous Substances Data: 135299-35-3(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 108-10-1 4-methyl-2-pentanone 
• 74-88-4 methyl iodide 

Downstream Products

• 91794-24-0 4-Hydroxy-2,2-dimethyl-3,4,5,6-tetrahydro-2H-pyrano<3,2-c>quinolin-5-one 
• 523-64-8 flindersine 

Relevant articles and documents

A new synthesis of flindersine

Ketene S,N-acetal from the carbethoxylated isobutyl methyl ketone undergoes thermal cyclization with N-phenyl to give 4-hydroxy-3-(3-methylbutanoyl)-2-thiomethylquinoline (III) which is transformed into the corresponding 4-chloro derivative (IV).The carbonyl group in the side chain at 3-position of VI is converted into the α,β-unsaturated ketone (V) followed by acid hydrolysis to afford 4-keto-2,2-dimethyl-3,4,5,6-tetrahydro-2H-pyranoquinolin-5-one (VI).Reduction of 4-keto group of VI and subsequent dehydration of the resulting alcohol furnishes flindersine (I).