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Cas No: 108-10-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 2000 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Cas No: 108-10-1
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply 4-methylpentan-2-one
Cas No: 108-10-1
No Data 1 1 Ality Chemical Corporation Contact Supplier
4-Methyl-2-pentanone CAS#108-10-1
Cas No: 108-10-1
No Data 1 Kilogram 30 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
Amadis Chemical offer CAS#108-10-1;CAT#A801806
Cas No: 108-10-1
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
High quality Methyl Isobutyl Keton,MIBK/cas 108-10-1
Cas No: 108-10-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 6000 Metric Ton/Month Wuxi TAA Chemical Industry Co.,LTD. Contact Supplier
4-Methyl-2-pentanone CAS:108-10-1
Cas No: 108-10-1
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 2500 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Cas No: 108-10-1
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
4-Methyl-2-pentanone 108-10-1
Cas No: 108-10-1
No Data 1 Metric Ton 100 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
BLOOM TECH Advanced API/Technology support 4-Methyl-2-pentanone CAS 108-10-1
Cas No: 108-10-1
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier

108-10-1 Usage

Physical properties

Clear, colorless, watery liquid with a mild, pleasant odor. Odor threshold concentration is 47 ppbv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m3 (100 ppbv) and 1.1 mg/m3 (270 ppbv), respectively (Hellman and Small, 1974).

Health Hazard

Vapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.


The National Toxicology Program conducted cancer bioassays by exposing groups of 50 male and 50 female F344 rats and B6C3F1 mice to MiBK vapor at 0, 450, 900, or 1800 ppm 6h/day, 5 days/ week for 2 years. Survival and body weight gain were decreased in male rats at 1800 ppm. Body weight gain was also decreased in male rats at 900 and in female mice at 1800ppm. A higher incidence of mineralization of the renal papilla was observed in male rats at all MiBK exposure levels. Chronic progressive nephropathy (CPN) and the incidences of adenoma and adenoma or carcinoma (combined) were increased for the male 1800 ppm exposure group. The severity of CPN and renal tubular hyperplasia was increased in all male rat exposure groups. An uncertain increase in mononuclear cell leukemia, adrenal medulla hyperplasia, and a positive trend for increases in benign or malignant pheochromocytomas (combined) were reported for the 1800 ppm male group. The NTP considered that there was some evidence of carcinogenic activity in male rats based on increased incidences of renal tubule neoplasms. None of the rodent bioassay results were considered clear evidence of carcinogenicity by NTP.

Potential Exposure

MIBK is used as a solvent; a denaturant; and as an extractant; in the manufacture of methyl amyl alcohol; as a solvent in paints, varnishes, and lacquers; as an alcohol denaturant; as a solvent in uranium extraction from fission products.

General Description

A clear colorless liquid with a pleasant odor. Flash point 73°F. Less dense than water. Vapors heavier than air.


Methyl isobutyl ketone (hexone, isobutyl methyl ketone, 4-methyl-2-pentanone) is an organic solvent similar in structure and use to methyl butyl ketone. In addition to its use as a solvent for paints, lacquers, and varnishes, methyl isobutyl ketone is used in extraction processes and as a denaturant for rubbing alcohol. Methyl isobutyl ketone is also used as a synthetic flavoring in some varieties of rum, candy, and cheese. Unlike methyl butyl ketone, methyl isobutyl ketone has not been found to occur naturally.

Air & Water Reactions

Highly flammable. 4-Methyl-2-pentanone is sensitive to air (may form explosive peroxides). Slightly soluble in water.

Environmental fate

Biological. Bridié et al. (1979) reported BOD and COD values of 2.06 and 2.16 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C and stirred for a period of 5 d. Heukelekian and Rand (1955) reported a 5-d BOD value of 1.51 g/g which is 55.5% of the ThOD value of 2.72 g/g. Photolytic. When synthetic air containing gaseous nitrous acid and 4-methyl-2-pentanone was exposed to artificial sunlight (λ = 300–450 nm), photooxidation products identified were acetone, peroxyacetal nitrate, and methyl nitrate (Cox et al., 1980). In a subsequent experiment, the OHinitiated photooxidation of 4-methyl-2-pentanone in a smog chamber produced acetone (90% yield) and peroxyacetal nitrate (Cox et al., 1981). Irradiation at 3130 ? resulted in the formation of acetone, propyldiene, and free radicals (Calvert and Pitts, 1966). Second-order photooxidation rate constants for the reaction of 4-methyl-2-butanone and OH radicals in the atmosphere are 1.4 x 10-10, 1.42 x 10-10, and 1.32 x 10-10 cm3/molecule?sec at 295, 299, and 300 K, respectively (Atkinson, 1985). The atmospheric lifetime was estimated to be 1–5 d (Kelly et al., 1994). Photolytic. Cox et al. (1980) reported a rate constant of 1.24 x 10-11 cm3/molecule?sec for the reaction of gaseous 4-methyl-2-pentanone with OH radicals based on a value of 8 x 10-12 cm3/molecule?sec for the reaction of ethylene with OH radicals. Chemical/Physical. 4-Methyl-2-pentanone will not hydrolyze in water because it does not contain a hydrolyzable functional group (Kollig, 1993).


4-Methyl-2-pentanone has a pleasant odor. May be prepared by hydrogenation of mesityl oxide over Ni at 160 - 190°C; also by oxidation of methyl isobutyl carbinol.

Synthesis Reference(s)

Journal of the American Chemical Society, 100, p. 5437, 1978 DOI: 10.1021/ja00485a031Tetrahedron Letters, 36, p. 2285, 1995 DOI: 10.1016/0040-4039(95)00191-ETetrahedron, 37, p. 3073, 1981 DOI: 10.1016/S0040-4020(01)98839-8


By hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.

Purification Methods

Reflux the ketone with a little KMnO4, wash it with aqueous NaHCO3, dry with CaSO4 and distil it. Acidic impurities are removed by passage through a small column of activated alumina. [Beilstein 1 IV 3305.]

Health Hazard

MIBK exhibits low to moderate toxicity.It is more toxic than acetone. Exposureto 200 ppm can cause irritation of theeyes, mucous membranes, and skin. Prolonged skin contact can leach out fat fromthe skin. Exposure to high concentrationscan cause nausea, headache, and narcosis. Animal studies indicate that this compound could probably cause kidney damage,with symptoms of a heavier kidney, higherkidney-to-body weight ratio, and tubularnecrosis. An increase in liver weight wasnoted, too, associated with its exposure inanimal subjects. In male rats the effect wasobserved at 2000 ppm on 2 weeks’ exposure(6 hours/day) (Phillips et al. 1987). Otherthan for the male rat kidney effect, the levelsup to 1000 ppm for 14 weeks had no significant toxicological effect. In another study,exposure to 3000 ppm in rats and mice wasfound to cause increased liver and kidneyweights, decrease in food consumption, incidence of dead fetuses, and reduced fetal bodyweight (Tyl et al. 1987).Ingestion of MIBK can result in narcosis and coma. A genetic toxicology studyof MIBK showed a negative response inthe bacterial mutation assays and the yeastmitotic gene conversion assay (Brooks et al.1988).LD50 value, oral (rat): 2080 mg/kgLD50 value, intraperitoneal (rat): 400 mg/kg.


In paints, glues, and cleaning agents; used in the plastic and petrol industries

Reactivity Profile

4-Methyl-2-pentanone is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. 4-Methyl-2-pentanone reacts violently with potassium tert-butoxide. 4-Methyl-2-pentanone reacts vigorously with reducing materials. .


MIBK is used as a solvent for gums, resins,nitrocellulose and cellulose ethers, and various fats, oils, and waxes.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.


Flammable, dangerous fire risk, explosivelimits in air 1.4–7.5%. Avoid ingestion and inhala-tion. Upper respiratory tract irritant, dizziness, andheadache. Possible carcinogen.


UN1245 Methyl isobutyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.

Chemical Properties

Methyl isobutyl ketone (MIBK) is a colorless liquid with a pleasant, sweet, fruity odor. The odor threshold can be as low as 0.10 ppm. It is 2% soluble in water by weight and with several other organic solvents. The lower explosive limit is 1.2% and the upper explosive limit is 8.0% at 200 °F. Methyl isobutyl ketone may be incompatible with strong oxidizers and potassium tert-butoxide.

Taste threshold values

Taste characteristics at 25 ppm: sweet, ethereal, banana and fruity with dairy nuances

Aroma threshold values

Detection: 240 to 640 ppb

Production Methods

Methyl isobutyl ketone can be manufactured by two processes . The first is a mixed ketone process where MiBK, diisobutyl ketone, and acetone are coproduced in a single reaction using isopropanol as a starting material. The second method is used to produce the majority of MiBK and involves a three-step reaction sequence in which diacetone alcohol and mesityl oxide are formed as intermediates.


Reported found in orange and lemon juice, grape; vinegar, baked potato, papaya, ginger, wheat bread, cheeses, milk, cooked egg, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushroom, trassi, sesame seed, buckwheat, wort, elder flower, Bourbon vanilla, clary and red sage, crab, clam and Chinese quince.


Able to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide; strong acids; aliphatic amines; reducing agents

Chemical Properties

4-Methyl-2-pentanone has a fruity, ethereal, spicy (on dilution) odor.

108-10-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (33346)  4-Methyl-2-pentanone, ACS, 98.5+%    108-10-1 500ml 320.0CNY Detail
Alfa Aesar (33346)  4-Methyl-2-pentanone, ACS, 98.5+%    108-10-1 1L 434.0CNY Detail
Alfa Aesar (33346)  4-Methyl-2-pentanone, ACS, 98.5+%    108-10-1 *4x500ml 772.0CNY Detail
Alfa Aesar (43170)  4-Methyl-2-pentanone, HPLC Grade, 99+%    108-10-1 1L 502.0CNY Detail
Alfa Aesar (43170)  4-Methyl-2-pentanone, HPLC Grade, 99+%    108-10-1 4L 945.0CNY Detail
Alfa Aesar (43170)  4-Methyl-2-pentanone, HPLC Grade, 99+%    108-10-1 *4x1L 1608.0CNY Detail
Alfa Aesar (43170)  4-Methyl-2-pentanone, HPLC Grade, 99+%    108-10-1 *4x4L 3213.0CNY Detail
Alfa Aesar (A11618)  4-Methyl-2-pentanone, 99%    108-10-1 500ml 184.0CNY Detail
Alfa Aesar (A11618)  4-Methyl-2-pentanone, 99%    108-10-1 2500ml 731.0CNY Detail
Sigma-Aldrich (537713)  4-Methyl-2-pentanone  ≥99% 108-10-1 537713-1L 635.31CNY Detail
Sigma-Aldrich (PHR1556)  MethylIsobutylKetone  pharmaceutical secondary standard; traceable to USP 108-10-1 PHR1556-3X1.2ML 791.15CNY Detail
Sigma-Aldrich (293261)  4-Methyl-2-pentanone  for HPLC, ≥99.5% 108-10-1 293261-100ML 617.76CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 4-Methyl-2-pentanone

1.2 Other means of identification

Product number -
Other names 4-methylpentan-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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