1356446-78-0

Basic information

• Product Name: Fosinopril impurity D
• Synonyms: Fosinopril impurity D;(4R)-4-Cyclohexyl-1-[(R)-[(S)-1-hydroxy-2-Methylpropoxy](4-phenylbutyl)phosphinyl]acetyl-L-proline Propionate SodiuM Salt;(2S,4R)-4-Cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
• CAS NO: 1356446-78-0
• Molecular Formula: C30H46NO7P
• Molecular Weight: 563.66
• Mol File: 1356446-78-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Fosinopril impurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Fosinopril impurity D(1356446-78-0)
• EPA Substance Registry System: Fosinopril impurity D(1356446-78-0)

Safety Data

• Hazardous Substances Data: 1356446-78-0(Hazardous Substances Data)

Upstream product

• 128948-00-5 C₁₉H₂₉O₆P 
• 90657-55-9 trans-4-cyclohexyl-L-proline hydrochloride 
• 31560-20-0 (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 103201-78-1 (2S,4S)-4-cyclohexylpyrrolidine-2-carboxylic acid 
• 96314-26-0 trans-4-phenyl-L-proline 
• 120851-71-0 (2S,4S)-1-Benzoyl-4-phenyl-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Preparation methods of antihypertensive Fosinopril sodium and key intermediate thereof

The invention relates to preparation methods of an antihypertensive Fosinopril sodium and a key intermediate thereof trans-4-phenyl-L-proline suitable for industrial production. Synthesis of the key intermediate trans-4-phenyl-L-proline has high chiral selectivity, and the method is simple and easy to operate.

Process for the preparation of fosinopril and intermediates thereof

The present invention relates to a process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[2-methyl-1-oxypropoxy) propoxy](4-phenylbutyl phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt (fosinopril sodium).

Process for the preparation of fosinopril and intermediates thereof

Process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[(2-methyl-1-oxypropoxy) propoxy](4-phenylbutyl) phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt.