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1357159-06-8

tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate

    Cas No: 1357159-06-8

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  • 1357159-06-8 Structure

  • Basic information

    1. Product Name: tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate
    2. Synonyms:
    3. CAS NO:1357159-06-8
    4. Molecular Formula:
    5. Molecular Weight: 468.555
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1357159-06-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate(1357159-06-8)
    11. EPA Substance Registry System: tert-butyl 1-(4-(2-oxo-8-phenyl-2H-pyrimido[1,2-b]pyridazin-7-yl)phenyl)cyclobutylcarbamate(1357159-06-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1357159-06-8(Hazardous Substances Data)

1357159-06-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1357159-06-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,1,5 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1357159-06:
(9*1)+(8*3)+(7*5)+(6*7)+(5*1)+(4*5)+(3*9)+(2*0)+(1*6)=168
168 % 10 = 8
So 1357159-06-8 is a valid CAS Registry Number.

1357159-06-8Relevant articles and documents

Diverse heterocyclic scaffolds as allosteric inhibitors of AKT

Kettle, Jason G.,Brown, Simon,Crafter, Claire,Davies, Barry R.,Dudley, Phillippa,Fairley, Gary,Faulder, Paul,Fillery, Shaun,Greenwood, Hannah,Hawkins, Janet,James, Michael,Johnson, Keith,Lane, Clare D.,Pass, Martin,Pink, Jennifer H.,Plant, Helen,Cosulich, Sabina C.

, p. 1261 - 1273 (2012/04/10)

Wide-ranging exploration of potential replacements for a quinoline-based inhibitor of activation of AKT kinase led to number of alternative, novel scaffolds with potentially improved potency and physicochemical properties. Examples showed predictable DMPK properties, and one such compound demonstrated pharmacodynamic knockdown of phosphorylation of AKT and downstream biomarkers in vivo and inhibition of tumor growth in a breast cancer xenograft model.

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