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FMOC-D-TRP-OPFP is a chemical compound that combines FMOC (9-fluorenylmethoxycarbonyl), D-TRP (D-tryptophan), and OPFP (octyloxyphenyl). It is a crucial component in peptide synthesis, particularly in solid-phase peptide synthesis, due to its ability to protect the amine group of the amino acid. The FMOC group is easily removed under mild acidic conditions, making it a popular choice for peptide synthesis. D-TRP is a modified form of the amino acid tryptophan, and OPFP is a protecting group used in peptide chemistry to block specific functional groups during synthesis.

136554-94-4

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  • (2,3,4,5,6-pentafluorophenyl) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoate

    Cas No: 136554-94-4

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136554-94-4 Usage

Uses

Used in Pharmaceutical Industry:
FMOC-D-TRP-OPFP is used as a protecting agent for the amine group of amino acids during peptide synthesis. Its ability to protect specific functional groups allows for the controlled and efficient production of peptides with desired properties and biological activities.
Used in Chemical Research:
FMOC-D-TRP-OPFP is used as a key component in the development of novel peptide-based drugs and therapeutic agents. Its role in protecting specific amino acid functional groups enables researchers to explore new peptide sequences and structures with potential applications in various therapeutic areas.
Used in Biochemistry and Molecular Biology:
FMOC-D-TRP-OPFP is used as a reagent in the synthesis of peptides for studying protein-protein interactions, enzyme substrate specificity, and other biological processes. Its ability to protect specific functional groups allows for the controlled synthesis of peptides with defined structures, facilitating the investigation of their biological functions and mechanisms of action.
Overall, FMOC-D-TRP-OPFP plays a vital role in the production of peptides and the development of new therapeutic agents, making it an essential component in various applications across the pharmaceutical, chemical research, and biochemistry industries.

Check Digit Verification of cas no

The CAS Registry Mumber 136554-94-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,5,5 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 136554-94:
(8*1)+(7*3)+(6*6)+(5*5)+(4*5)+(3*4)+(2*9)+(1*4)=144
144 % 10 = 4
So 136554-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H21F5N2O4/c33-25-26(34)28(36)30(29(37)27(25)35)43-31(40)24(13-16-14-38-23-12-6-5-7-17(16)23)39-32(41)42-15-22-20-10-3-1-8-18(20)19-9-2-4-11-21(19)22/h1-12,14,22,24,38H,13,15H2,(H,39,41)/t24-/m1/s1

136554-94-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H66257)  N-Fmoc-D-tryptophan pentafluorophenyl ester, 97%   

  • 136554-94-4

  • 250mg

  • 196.0CNY

  • Detail
  • Alfa Aesar

  • (H66257)  N-Fmoc-D-tryptophan pentafluorophenyl ester, 97%   

  • 136554-94-4

  • 1g

  • 588.0CNY

  • Detail
  • Alfa Aesar

  • (H66257)  N-Fmoc-D-tryptophan pentafluorophenyl ester, 97%   

  • 136554-94-4

  • 5g

  • 2352.0CNY

  • Detail

136554-94-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,3,4,5,6-pentafluorophenyl) 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoate

1.2 Other means of identification

Product number -
Other names fmoc-d-trp-opfp

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136554-94-4 SDS

136554-94-4Relevant articles and documents

PREPARATION OF PENTAFLUOROPHENYL ESTERS OF FMOC PROTECTED AMINO ACIDS WITH PENTAFLUOROPHENYL TRIFLUOROACETATE

Green, Michael,Berman, Judd

, p. 5851 - 5852 (1990)

A high yield procedure for the preparation of pentafluorophenyl esters of Nα-9-fluorenylmethyloxycarbonyl protected amino acids is described.The procedure utilizes pentafluorophenyl trifluoroacetate.

9-Fluorenylmethyl Pentafluorophenyl Carbonate as a Useful Reagent for the Preparation of N-9-Fluorenylmethyloxycarbonylamino Acids and their Pentafluorophenyl Esters

Schoen, Istvan,Kisfaludy, Lajos

, p. 303 - 305 (2007/10/02)

9-Fluorenylmethyl pentafluorophenyl carbonate is a useful reagent for the efficient, side reaction-free introduction of N-9-fluorenylmethyloxycarbonyl protecting group into amino acids and for the subsequent preparation of their pentafluorophenyl esters.Some new compounds of both types are described.

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