439613-95-3

Basic information

• Product Name: H-Phe-Val-Trp-Ile-NH₂
• Synonyms: H-Phe-Val-Trp-Ile-NH₂
• CAS NO: 439613-95-3
• Molecular Weight: 562.712
• Mol File: 439613-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-Phe-Val-Trp-Ile-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: H-Phe-Val-Trp-Ile-NH₂(439613-95-3)
• EPA Substance Registry System: H-Phe-Val-Trp-Ile-NH₂(439613-95-3)

Safety Data

• Hazardous Substances Data: 439613-95-3(Hazardous Substances Data)

Upstream product

• 86060-87-9 Fmoc-Val-OPfp 
• 86060-89-1 N-α-Fmoc-L-isoleucine pentafluorophenyl ester 
• 86069-87-6 N-α-fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl ester 
• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 

Relevant articles and documents

Design and Synthesis of novel tetra-peptide motilin agonists

A series of novel tetra-peptide motilin agonists, having the general structure H-Phe-Val-X-Ile-NH2, were designed, on the basis of structure-activity relationship studies of motilin. Peptides, in which X is a side chain substituted tryptophan residue, have agonistic activity. H-Phe-Val-Trp(2′-CH2CH2OH)-Ile-NH2(7), H-Phe-Val-Trp(2′-SCH3)-Ile-NH2(8), and H-Phe-Val-Trp(2′-SCH2CH2CH3)-Ile-NH 2 (9), showed an EC50 for contractile activity in the rabbit smooth muscle of 14.1±3.2, 12.9±4.1, and 4.6±1.6 μM, respectively. Interaction of the tryptophan aliphatic side chain with motilin receptor appears to influence the signal transduction via motilin receptor.