139272-67-6 Usage
Description
Aceclofenac Ethyl Ester is a white solid substance that is identified as a potential impurity in commercial preparations of aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used for treating various conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses
Used in Pharmaceutical Industry:
Aceclofenac Ethyl Ester is used as an impurity in the production of aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID). Its presence in commercial preparations is significant for ensuring the quality, safety, and efficacy of the final drug product. The pharmaceutical industry closely monitors and controls the levels of Aceclofenac Ethyl Ester to maintain the desired therapeutic effects and minimize potential side effects associated with the use of aceclofenac.
Used in Quality Control and Regulatory Compliance:
Aceclofenac Ethyl Ester is used as a reference substance in the development and validation of analytical methods for the quantification of impurities in aceclofenac drug products. This application is crucial for quality control and regulatory compliance, as it helps to ensure that the drug meets the required standards for purity, potency, and safety.
Used in Research and Development:
Aceclofenac Ethyl Ester serves as a valuable compound for researchers in the field of pharmaceutical chemistry and drug development. It can be used to study the chemical properties, stability, and interactions of aceclofenac and its related compounds. Additionally, it may be utilized in the development of new drug formulations, drug delivery systems, or novel therapeutic approaches that build upon the anti-inflammatory and analgesic properties of aceclofenac.
Check Digit Verification of cas no
The CAS Registry Mumber 139272-67-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,2,7 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 139272-67:
(8*1)+(7*3)+(6*9)+(5*2)+(4*7)+(3*2)+(2*6)+(1*7)=146
146 % 10 = 6
So 139272-67-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H17Cl2NO4/c1-2-24-17(23)11-25-16(22)10-12-6-3-4-9-15(12)21-18-13(19)7-5-8-14(18)20/h3-9,21H,2,10-11H2,1H3
139272-67-6Relevant articles and documents
Novel hybrids of drug with bioactive heterocycles for enhancing biological activity
Valentina, Parthiban,Ilango, Kaliappan,Kathiravan, Muthu K.
, p. 1382 - 1390 (2016/10/20)
A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and synthesised 6a–j. The structural integrity was confirmed by analytical methods. The hybrid molecules were subjected to in vitro cytotoxic studies against four human cancer cell lines PA‐1, OAW‐42, T47-D and MCF‐7 by MTT assay method. The results indicate that the hybrid molecules bearing halogen on phenyl ring in 6th position of triazolo-thiadiazole exhibited significant cytotoxic activity. The test compounds were also screened for antifungal activity against two strains.