141635-23-6Relevant articles and documents
Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases
Sudhamalla, Babu,Wang, Sinan,Snyder, Valerie,Kavoosi, Sam,Arora, Simran,Islam, Kabirul
supporting information, p. 10263 - 10269 (2018/08/01)
Ten-eleven translocation (TET) enzymes employ O2, earth-abundant iron, and 2-ketoglutarate (2KG) to perform iterative C-H oxidation of 5-methylcytosine in DNA to control expression of the mammalian genome. Given that more than 60 such C-H oxyge