5619-07-8

Basic information

• Product Name: DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
• Synonyms: METHYL 2-AMINO-3-PHENYLPROPANOATE HYDROCHLORIDE;TIMTEC-BB SBB003394;Methyl-d,1-phenylalanine hydrochloride;(±)-Phenylalanine methyl ester hydrochloride;DL-Phe-OMe hydrochloride;Methyl DL-phenylalaninate hydrochloride;DL-Phe-OMe HCl;H-DL-PHE-OME HCL
• CAS NO: 5619-07-8
• Molecular Formula: C₁₀H₁₄NO₂*Cl
• Molecular Weight: 215.68
• EINECS: 227-049-2
• Mol File: 5619-07-8.mol
• Article Data: 33

Chemical Properties

• Melting Point: 158-162°C
• Boiling Point: 264.2 °C at 760 mmHg
• Flash Point: 126 °C
• Appearance: /
• Vapor Pressure: 0.00986mmHg at 25°C
• Storage Temp.: -15°C
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• Water Solubility: Slightly soluble in water.
• Sensitive: Hygroscopic
• BRN: 3597947
• CAS DataBase Reference: DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE(5619-07-8)
• EPA Substance Registry System: DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE(5619-07-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5619-07-8(Hazardous Substances Data)

Usage

Uses

DL-Phenylalanine methyl ester hydrochloride, is an aminoacid which is widely used in pharmaceuticals and foods.

InChI:InChI=1/C10H13NO2.ClH/c1-13-10(12)9(11)7-8-5-3-2-4-6-8;/h2-6,9H,7,11H2,1H3;1H

Upstream product

• 100020-81-3 β-chloro-β-phenylalanine methyl ester hydrochloride 
• 69-96-5 Phenylserin 
• 150-30-1 Phenylalanine 
• 77-76-9 2,2-dimethoxy-propane 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 21132-20-7 (RS)-ethyl-2-acetamido-2-cyano-3-phenylpropanoate 
• 67-56-1 methanol 
• 27172-85-6 phenylalanine methyl ester hydrochloride 
• 112792-62-8 trans-dichlorobis(dehydrophenylalanin-methylester)palladium(II) 
• 100-52-7 benzaldehyde 
• 112302-89-3 methyl 2-(N,N-dibenzylamino)-3-phenylpropanoate 
• 90315-76-7 PChd-Phe-OMe 
• 126027-31-4 DL-β-chloro-β-phenylalanine hydrochloride 

Downstream Products

• 4833-87-8 N-(N,N-phthaloyl-glycyl)-DL-phenylalanine-methyl ester 
• 41888-85-1 N-(N-benzyloxycarbonyl-glycyl)-DL-phenylalanine methyl ester 
• 17193-31-6 (R,S)-2-amino-3-phenylpropionamide 
• 122389-58-6 N-stearoyl-phenylalanine methyl ester 
• 58219-64-0 3-Phenyl-2-[(Z)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-acryloylamino]-propionic acid methyl ester 
• 24692-80-6 2-(2-Formylamino-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester 
• 83851-86-9 (5-nitro-2-thenoyl)-DL-Phe-OMe 
• 68802-01-7 N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex 
• 145512-66-9 (R)-α-methylbenzylcarbamoyl-DL-phenylalanine methyl ester 
• 100992-42-5 methyl 2-(4-chlorobenzylidene)amino-3-phenylpropionate 
• 70288-75-4 2-(Methoxycarbonalamino)-3-phenylpropionsaeure-methylester 
• 126376-18-9 DL-2-Amino-1,1-bis(4-methoxyphenyl)-3-phenyl-1-propanol 
• 102428-90-0 1-methyl-2-<<<<2(S)-(methoxycarbonyl)-3-phenyl>propanoyl>amino>methyl>-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine 
• 103676-09-1 2-amino-N-benzyl-3-phenylpropionamide 

Relevant articles and documents

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported. Levulinic acid was applied as a bifunctional substrate containing both carbonyl and acid moieties suitable for the Ugi reaction. This article provides a facile and convenient one-pot procedure for the synthesis of peptide-like heterocyclic molecules containing 2-pyrrolidone (γ-lactam), amide and ester functional groups with good to excellent yields.

Chiral polycyclic tropane compound as well as preparation method and application thereof

The invention provides a chiral polycyclic tropane compound as well as a preparation method and application thereof. The invention specifically relates to a tropane compound shown as a formula I, or a salt thereof, or a stereoisomer thereof, or a crystal form thereof, and a preparation method and application thereof. The preparation method disclosed by the invention is simple in process, mild in reaction condition and high in yield, and the obtained product has excellent enantioselectivity and diastereoselectivity. Experiments prove that the tropane compound can effectively inhibit various tumor cells, especially lung cancer cells, melanoma cells, breast cancer cells, in-situ pancreatic cancer cells and pancreatic cancer cells, so that the compound has a wide prospect in preparation of drugs for preventing and/or treating tumors.

Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion-Pair Photocatalysis

A bioinspired, intermolecular radical Stetter reaction of α-keto acids and aldehydes is disclosed that is contingent on a formal “radical umpolung” concept. Enabled by secondary amine activation, electrostatic recognition ensures that the α-ketocarboxylic acids, which function as latent acyl radicals, are proximal to the in situ generated iminium salts. This photoactive contact ion pair is an electron donor–acceptor (EDA) complex, and undergoes facile single electron transfer (SET) and rapid decarboxylation prior to radical–radical recombination. Importantly, decarbonylation is mitigated by this strategy. The initial computational validation on which the process is predicated matches closely with experiment. Synergising organo- and photocatalysis activation principles finally expands the mechanistic and synthetic scope of the classic Stetter reaction to include α,β-unsaturated aldehydes as acceptors.