1427086-87-0

Basic information

• Product Name: PMB-L-Val-NH₂
• Synonyms: PMB-L-Val-NH₂
• CAS NO: 1427086-87-0
• Molecular Weight: 236.314
• Mol File: 1427086-87-0.mol

Chemical Properties

• CAS DataBase Reference: PMB-L-Val-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: PMB-L-Val-NH₂(1427086-87-0)
• EPA Substance Registry System: PMB-L-Val-NH₂(1427086-87-0)

Safety Data

• Hazardous Substances Data: 1427086-87-0(Hazardous Substances Data)

Upstream product

• 3014-80-0 (S)-2-amino-3-methylbutanamide hydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Synthesis of the Aminovinylcysteine-Containing C-Terminal Macrocycle of the Linaridins

N-Phthalimido-d-cysteine allyl ester was S-alkylated with 2-iodoethanol. The derived β-thioaldehyde was condensed with Nα-tetrachlorophthalimidovalinamide to afford a Z-thioenamide. Removal of the tetrachlorophthalimido protecting group and homologation with N-Boc-l-leucine afforded the linear tripeptide. Removal of the Boc and allyl protecting groups, followed by carbodiimide-mediated cyclization, led to the 13-membered ring with the aminovinylcysteine moiety embedded. This constitutes the C-terminal macrocycle of all known members of the linardin family of peptides, including the antileukemia agent, cypemycin.

Potassium formate as a small molecule switch: Controlling oxidation-reduction behaviour in a two-step sequence

A one-pot reaction sequence is described in which the addition of one compound allowed switching between simultaneously occurring oxidation and reduction reactions.