14300-06-2

Basic information

• Product Name: N-butyl-N-nitrosoacetamide
• CAS NO: 14300-06-2
• Molecular Formula: C₆H₁₂N₂O₂
• Molecular Weight: 144.1717
• Mol File: 14300-06-2.mol

Chemical Properties

• Boiling Point: 182°C at 760 mmHg
• Flash Point: 63.9°C
• Density: 1.05g/cm³
• Vapor Pressure: 0.827mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: N-butyl-N-nitrosoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-N-nitrosoacetamide(14300-06-2)
• EPA Substance Registry System: N-butyl-N-nitrosoacetamide(14300-06-2)

Safety Data

• Hazardous Substances Data: 14300-06-2(Hazardous Substances Data)

Upstream product

• 1119-49-9 N-butylacetamide 

Downstream Products

• 123-86-4 acetic acid butyl ester 
• 64-19-7 acetic acid 
• 103-84-4 Acetanilid 

Relevant articles and documents

Reaction of amides with nitric oxide (NO)

Amides were allowed to react with nitric oxide in aprotic and non- ethereal solvents to give the corresponding N-nitroso derivatives. The reaction was accelerated by addition of oxygen. The solvent effect revealed that the reaction did not proceed in the presence of protic media.

Reaction of N-Nitroso- and N-Nitro-N-alkylamides with Amines

Several N-nitroso- and N-nitrocarboxamides have been characterized by 1H and 13C NMR spectroscopy.These compounds react with ammonia and aliphatic amines to afford mainly carboxamides of general formula RCONH2, RCONHR', or RCONR'R''.N-Nitrosocarboxamides and aromatic amines give poor yields of RCONHAr; by contrast, N-nitrocarboxamides and aromatic amines lead to RCONHAr in good yields.The higher thermal stability of the N-nitroamides as compared to N-nitrosoamides is advantageous in this connection; nevertheless, the principal advantage of the NNO2 group appears to be that it activates the nucleophilic attack to the carbonyl of the amide function more than the NNO group, as has been demonstrated by competitive experiments.The reaction of N-nitroso- and N-nitro-N-methylsulfonamides with ammonia and diethylamine has been studied as well; whereas N-methyl-N-nitro-p-toluenesulfonamide reacts as N-nitrocarboxamides, transnitration is predominant with N-methyl-N-nitroso-p-toluenesulfonamide.