143062-73-1

Basic information

• Product Name: (1R,2S)-Fluorocyclopropylamine tosylate
• Synonyms: cis-2-Fluorocyclopropanamine 4-methylbenzenesulfonate;Cyclopropanamine, 2-fluoro-, cis-(±)-, 4-methylbenzenesulfonate
• CAS NO: 143062-73-1
• Molecular Formula: C₃H₆FN*C₇H₈O₃S
• Molecular Weight: 247.29
• Mol File: 143062-73-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (1R,2S)-Fluorocyclopropylamine tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-Fluorocyclopropylamine tosylate(143062-73-1)
• EPA Substance Registry System: (1R,2S)-Fluorocyclopropylamine tosylate(143062-73-1)

Safety Data

• Hazardous Substances Data: 143062-73-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2S)-Fluorocyclopropylamine tosylate is utilized as a precursor in organic synthesis, specifically for the preparation of fluorinated pharmaceuticals. The fluorine atom in the cyclopropane ring endows the molecule with distinctive properties that are advantageous in the development of novel drugs.
Used in Agrochemical Industry:
In addition to pharmaceuticals, (1R,2S)-Fluorocyclopropylamine tosylate also serves as a starting material in the synthesis of fluorinated agrochemicals. Its unique structural features contribute to the creation of new compounds with potential applications in agriculture.
Used in Materials Science:
The tosylate group in (1R,2S)-Fluorocyclopropylamine tosylate acts as a leaving group in chemical reactions, facilitating the manipulation of the molecule's structure. This characteristic makes it a useful component in the development of advanced materials for various applications in materials science.
Overall, (1R,2S)-Fluorocyclopropylamine tosylate is a versatile chemical intermediate with broad applications across different industries, particularly in the development of innovative products for medicine, agriculture, and materials science.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 

Downstream Products

• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 
• 142977-48-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1R,2S)-2-fluorocyclopropylcarbamate 
• 143059-80-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1S,2R)-2-fluorocyclopropylcarbamate 

Relevant articles and documents

Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions

cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoin-dol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.

Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro