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144163-97-3

144163-97-3

Identification

Synonyms:(4-Nitrophenyl)thiazol-5-ylmethyl carbonate;

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Safety information and MSDS view more

  • Signal Word:No signal word.

  • Hazard Statement:none

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
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  • Manufacture/Brand:Usbiological
  • Product Description:Thiazolylmethyl-4-nitrophenylcarbonate
  • Packaging:10mg
  • Price:$ 446
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Thiazolylmethyl-4-nitrophenylcarbonate
  • Packaging:250mg
  • Price:$ 95
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Thiazolylmethyl-4-nitrophenylcarbonate
  • Packaging:25 mg
  • Price:$ 890
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Carbonic acid 4-nitrophenyl ester thiazol-5-ylmethyl ester 95%
  • Packaging:5g
  • Price:$ 1568
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Carbonic acid 4-nitrophenyl ester thiazol-5-ylmethyl ester 95%
  • Packaging:1g
  • Price:$ 826
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  • Manufacture/Brand:Crysdot
  • Product Description:4-Nitrophenyl(thiazol-5-ylmethyl)carbonate 97%
  • Packaging:500g
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  • Manufacture/Brand:Chemenu
  • Product Description:((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate 95%+
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:Carbonic acid 4-nitro-phenyl ester thiazol-5-ylmethyl ester 95%
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:Carbonic acid 4-nitro-phenyl ester thiazol-5-ylmethyl ester 95%
  • Packaging:25 G
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:Carbonic acid 4-nitro-phenyl ester thiazol-5-ylmethyl ester 95%
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Relevant articles and documentsAll total 12 Articles be found

Design and synthesis of selenazole-substituted ritonavir analogs

Qiao, Junfei,Zhao, Chuanfang,Liu, Jun,Du, Yuguo

, p. 2379 - 2381 (2018)

With the help of Surflex-Dock calculation, two ritonavir analogs in which one thioazole unit was replaced by selenazole have been designed and synthesized. The key selenazole structure was constructed from β-azido diselenide through a cascade diselenide cleavage/selenocarbonylation/Staudinger reduction/aza-Wittig reaction and a following MnO2 oxidation. The accordingly prepared compounds exhibited good anti-HIV-1 (IIIB) activities comparable to that of the original ritonavir, as well as the positive SI values.

INHIBITORS OF CYTOCHROME P450

-

Paragraph 0878, (2015/11/10)

The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS

-

Page/Page column 188-189, (2008/06/13)

The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

Process route upstream and downstream products

Process route

thiazol-5-yl-methanol
38585-74-9

thiazol-5-yl-methanol

bis-(p-nitrophenyl) carbonate
5070-13-3

bis-(p-nitrophenyl) carbonate

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Conditions
Conditions Yield
With triethylamine; In dichloromethane; for 12h;
With triethylamine; In dichloromethane; Industry scale;
With triethylamine; In dichloromethane; for 12h;
4.7 g
With triethylamine; In dichloromethane; at 25 - 30 ℃; for 3h;
135.5 g
thiazol-5-yl-methanol
38585-74-9

thiazol-5-yl-methanol

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 20 ℃; for 4h;
95%
With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 1h;
78%
With 4-methyl-morpholine; In dichloromethane; for 1h; Adding at 0 °ree;C;
78%
4-methyl-morpholine
109-02-4

4-methyl-morpholine

thiazol-5-yl-methanol
38585-74-9

thiazol-5-yl-methanol

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Conditions
Conditions Yield
In methanol; dichloromethane; chloroform;
5.9 g (78%)
In methanol; dichloromethane; chloroform;
5.9 g (78%)
In methanol; dichloromethane; chloroform;
5.9 g (78%)
In methanol; dichloromethane; chloroform;
5.9 g (78%)
In methanol; dichloromethane; chloroform;
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Conditions
Conditions Yield
With pyridine; In ethyl acetate;
((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Conditions
Conditions Yield
N-ritonavir
176655-55-3

N-ritonavir

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

ritonavir
155213-67-5

ritonavir

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethyl acetate; at 50 - 60 ℃; for 9h;
85.29%
((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

ritonavir
155213-67-5

ritonavir

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 16 percent / tetrahydrofuran / 4 h / Ambient temperature
2: 1-hydroxybenzotriazole hydrate, N-ethyl-N'-<(dimethylamino)propyl>carbodiimide / tetrahydrofuran / 16 h / Ambient temperature
With N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; 1-hydroxybenzotriazol-hydrate; In tetrahydrofuran;
(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
144163-85-9

(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

(2S,3S,5S)-5-(t-butyloxycarbonylamino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane
162849-95-8

(2S,3S,5S)-5-(t-butyloxycarbonylamino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane

Conditions
Conditions Yield
(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane; ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate; In acetonitrile; at 20 ℃; for 0.333333h;
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 48h;
94%
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 5h; Inert atmosphere;
90%
With triethylamine; In tetrahydrofuran;
87%
In ethyl acetate; N,N-dimethyl-formamide;
6.53 g (80%)
In tetrahydrofuran;
(S)-N-((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamide

(S)-N-((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamide

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

Cobicistat

Cobicistat

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 30 - 40 ℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;
95%
With ascorbic acid; In isopropyl alcohol; at 25 - 30 ℃; for 18h; Temperature;
1.2 g
methyl (2S)-2-amino-3-phenylpropanoate
2577-90-4

methyl (2S)-2-amino-3-phenylpropanoate

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3

((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate

methyl N-[(1,3-thiazol-5-ylmethoxy)carbonyl]-L-phenylalaninate

methyl N-[(1,3-thiazol-5-ylmethoxy)carbonyl]-L-phenylalaninate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
90%

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